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The pattern of restenosis and vascular remodelling after cold-end radioactive stent implantation.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kay, Ipek Wardeh, Alexander Jacques Kozuma, Ken Sianos, Georgios Regar, Evelyn Knook, Marco A. H. Thury, Attila |
| Copyright Year | 2001 |
| Abstract | BACKGROUND Edge restenosis is a major problem after radioactive stenting. The cold-end stent has a radioactive mid-segment (15.9 mm) and non-radioactive proximal and distal 5.7 mm segments. Conceptually this may negate the impact of negative vascular remodelling at the edge of the radiation. METHOD AND RESULTS ECG-gated intravascular ultrasound with three-dimensional reconstruction was performed post-stent implantation and at the 6-month follow-up to assess restenosis within the margins of the stent and at the stent edges in 16 patients. Angiographic restenosis was witnessed in four patients, all in the proximal in-stent position. By intravascular ultrasound in-stent neointimal hyperplasia, with a >50% stented cross-sectional area, was seen in eight patients. This was witnessed proximally (n=2), distally (n=2) and in both segments (n=4). Echolucent tissue, dubbed the 'black hole' was seen as a significant component of neointimal hyperplasia in six out of the eight cases of restenosis. Neointimal hyperplasia was inhibited in the area of radiation: Delta neointimal hyperplasia=3.72 mm3 (8.6%); in-stent at the edges of radiation proximally and distally Delta neointimal hyperplasia was 7.9 mm3 (19.0%) and 11.4 mm3 (25.6%), respectively (P=0.017). At the stent edges there was no significant change in lumen volume. CONCLUSIONS Cold-end stenting results in increased neointimal hyperplasia in in-stent non-radioactive segments. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/eurheartj/22/15/10.1053_euhj.2000.2542/1/1311.pdf?Expires=1493042941&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=S5vhH00~u6K~FTCVmG8LWkcUVHl4CkDBkN4eRvVrUniHkmTxHsBS1QaSNk4yh-9scqcnhzDJDhLMhWVHPXTPt1mz3YCrt3PlzmhfCjQ5gxFX1kCjOL0Air1-gMa2GZH3bBanCK2nf5bWKP2~fOdJm~qQpCH~Q0~wD9Fx1q7BE~EixKtCPCP6nE3wmPac7LW1zFGsp~i4Dc7lrgPnQHjeavWUdz-zVKpdWJeTqK-5c8HNsHkXRgsgLxfqReBDOs7rDan7zL1orUUbTGTFgrFpraNR5tT0TcS3KAZ4Kk3Xzp2yLHH~VvfakBQyW4SGrxgUDK1V2ro7tOJPY0VRSSfKmw__ |
| PubMed reference number | 11465963v1 |
| Volume Number | 22 |
| Issue Number | 15 |
| Journal | European heart journal |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiolymphoid hyperplasia Brachytherapy Cerebrovascular Disorders Cubic Millimeter Intravascular ultrasound Mobitz type I incomplete atrioventricular block Patients Radioactivity Stent Device Component Stent, device Structure of lumen of body system restenosis |
| Content Type | Text |
| Resource Type | Article |
