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Serum and salivary cortisol in the diagnosis of adrenal insufficiency and as a predictor of the outcome in patients with severe sepsis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mello, Rômulo Carvalho Vaz De Sad, Eduardo Fonseca Andrade, Bertha Coelho Neves, Suzane Pretti Figueiredo Santos, Silvana Maria Elói Sarquis, Marta Maria S. Marik, Paul Ellis Dias, Eduardo Pimentel |
| Copyright Year | 2011 |
| Abstract | OBJECTIVES To compare salivary with serum total cortisol in patients with severe sepsis, postoperative patients and healthy controls. MATERIALS AND METHODS Serum total cortisol was determined by chemiluminescence immunoassay; salivary cortisol was determined by enzyme immunoassay. RESULTS In patients with severe sepsis, median concentration of salivary cortisol was 14.0 and 2.6 higher than that of postoperative patients and healthy subjects. In postoperative patients, salivary cortisol was 5.4 times higher than in control patients. Serum total cortisol was also higher in patients with severe sepsis than in controls and postoperative patients. This increment, however, was much lower (2.33 and 1.64, respectively). Patients with a salivary cortisol greater than 7.2 µg/dL had a mortality rate of 80%, a statistically significant result when compared with the group with lower cortisol levels (Z = 2.38 and p < 0.05). CONCLUSIONS Salivary cortisol in critically ill patients may be a better laboratory indicator of cortisol levels than serum total cortisol. |
| Starting Page | 35 |
| Ending Page | 40 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.scielo.br/pdf/abem/v55n7/04.pdf |
| PubMed reference number | 22147093v1 |
| Volume Number | 55 |
| Issue Number | 7 |
| Journal | Arquivos brasileiros de endocrinologia e metabologia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adrenal Glands Adrenal gland hypofunction Chemiluminescence Cortisol Measurement Critical Illness Eighty Enzyme Immunoassay Hydrocortisone Immunoassay method Immunoenzyme Procedure Increment Patients Salivary Gland Diseases Severe Sepsis |
| Content Type | Text |
| Resource Type | Article |
