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Akt/mTOR signalling in myelination.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Norrmén, Camilla Suter, Ueli |
| Copyright Year | 2013 |
| Abstract | Akt signalling has emerged as one of the major pathways involved in myelination, implicated in the regulation of several steps during the development of myelinating Schwann cells and oligodendrocytes. One of the main pathways intimately linked with Akt is mTOR [mammalian (or mechanistic) target of rapamycin] signalling. Recent evidence suggests that many processes attributed to the Akt pathway in myelination depend, at least partly, on mTOR signalling. In the present mini-review, we summarize the major aspects of Akt/mTOR signalling and myelination, and how they appear to be linked. We focus on the PNS (peripheral nervous system), but also cover the key points of CNS (central nervous system) myelination, pointing out differences and similarities between the PNS and the CNS. |
| Starting Page | 479 |
| Ending Page | 479 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.biochemsoctrans.org/content/ppbiost/41/4/944.full.pdf |
| PubMed reference number | 23863161v1 |
| Alternate Webpage(s) | https://doi.org/10.1042/BST20130046 |
| DOI | 10.1042/bst20130046 |
| Journal | Biochemical Society transactions |
| Volume Number | 41 |
| Issue Number | 4 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CNS disorder FRAP1 protein, human Oligodendroglia Peripheral Nervous System Proto-Oncogene Proteins c-akt Sirolimus biological signaling myelination |
| Content Type | Text |
| Resource Type | Article |
