NDLI: Cotargeting survival signaling pathways in cancer.

Please wait, while we are loading the content...

Cotargeting survival signaling pathways in cancer.

Content Provider	Semantic Scholar
Author	Grant, Steven
Copyright Year	2008
Abstract	Mammalian target of rapamycin (mTOR) is a component of a signaling pathway (PTEN/PI3K/AKT) that is frequently dysregulated in cancer. However, its precise relationship to the MAPK cascade (Ras/Raf/MEK/ERK), another pathway often implicated in tumorigenesis, has not been well defined. Recent evidence from tissue specimens obtained from patients who have received mTOR inhibitors suggests that ERK may be activated in response to mTOR interruption. In this issue of the JCI, Waugh Kinkade et al. and Carracedo et al. examine the relationship between these pathways in prostate and breast cancer cell model systems (see the related articles beginning on pages 3051 and 3065, respectively). Their findings suggest a link between inhibition of mTOR and ERK activation, possibly reflecting interruption of a novel negative S6K1-dependent feedback loop. Significantly, both groups observed that simultaneous inhibition of MEK/ERK and mTOR resulted in substantially enhanced antitumor effects both in vitro and in vivo. Together, these findings suggest that concurrent interruption of complementary signaling pathways warrants further investigation in cancer therapy.
Starting Page	16
Ending Page	22
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/36000/36898/JCI0836898.v2.pdf
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/36000/36898E1/JCI0836898E1.v1.pdf
PubMed reference number	18725993v1
Alternate Webpage(s)	https://doi.org/10.1172/JCI36898
DOI	10.1172/jci36898
Journal	The Journal of clinical investigation
Volume Number	118
Issue Number	9
Language	English
Access Restriction	Open
Subject Keyword	Breast Cancer Cell Carcinogenesis Cascade Device Component FRAP1 protein, human In Vitro [Publication Type] MAPK-ERK Kinases Mammary Neoplasms Patients Proto-Oncogene Proteins c-akt Signal Transduction Pathways Sirolimus Specimen
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling.

Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells.

Akt/mTOR signalling in myelination.

UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells

It Takes Two to Tango: Dual Inhibition of PI3K and MAPK in Rhabdomyosarcoma

The Role of Everolimus in the Treatment of Breast Cancer

Pten inactivation and the emergence of androgen-independent prostate cancer.

Cotargeting survival signaling pathways in cancer.

Similar Documents

Wedelolactone inhibits breast cancer-induced osteoclastogenesis by decreasing Akt/mTOR signaling.

Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance

Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells.

Akt/mTOR signalling in myelination.

UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells

It Takes Two to Tango: Dual Inhibition of PI3K and MAPK in Rhabdomyosarcoma

The Role of Everolimus in the Treatment of Breast Cancer

Pten inactivation and the emergence of androgen-independent prostate cancer.

Cotargeting survival signaling pathways in cancer.