NDLI: A New Perspective on the Heterogeneity of Cancer Glycolysis

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A New Perspective on the Heterogeneity of Cancer Glycolysis

Content Provider	Semantic Scholar
Author	Neugent, Michael L. Goodwin, Justin Sankaranarayanan, Ishwarya Yetkin, Celal Emre Hsieh, Meng-Hsiung Kim, Jung-whan
Copyright Year	2018
Abstract	Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has emphasized a uniformly elevated aerobic glycolysis as a critical feature of tumorigenecity. This led to extensive efforts of targeting glycolysis in human cancers. However, clinical attempts to target glycolysis and glucose metabolism have proven to be challenging. Recent advancements revealing a high degree of metabolic heterogeneity and plasticity embedded among various human cancers may paint a new picture of metabolic targeting for cancer therapies with a renewed interest in glucose metabolism. In this review, we will discuss diverse oncogenic and molecular alterations that drive distinct and heterogeneous glucose metabolism in cancers. We will also discuss a new perspective on how aberrantly altered glycolysis in response to oncogenic signaling is further influenced and remodeled by dynamic metabolic interaction with surrounding tumor-associated stromal cells.
Starting Page	10
Ending Page	18
Page Count	9
File Format	PDF HTM / HTML
PubMed reference number	29212302v1
Alternate Webpage(s)	https://doi.org/10.4062/biomolther.2017.210
DOI	10.4062/biomolther.2017.210
Journal	Biomolecules & therapeutics
Volume Number	26
Language	English
Access Restriction	Open
Subject Keyword	Cell Proliferation Embedding Glycolysis Hyperplasia Malignant Neoplasms Metabolic Process, Cellular Stromal Cells cellular targeting glucose metabolism
Content Type	Text
Resource Type	Article

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