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Impact of stromal microenvironment on metabolic phenotypes in breast cancer: evidence for stroma-influenced Warburg effect
| Content Provider | Semantic Scholar |
|---|---|
| Author | Brauer, Heather Ann Makowski, Liza Hoadley, Katherine A. Lang, Lindsay J. Freemerman, Alex J. Perou, Charles M. Troester, Melissa A. |
| Copyright Year | 2012 |
| Abstract | Background Cancer cells have altered metabolism, with an increased rate of glucose uptake, increased glycolysis, and due to the Warburg phenomenon, increased production of biomass (amino acids and nucleic acids) as metabolic byproducts. Association of these metabolic changes with breast cancer subtype and tumor gene expression has not been evaluated, nor is it well understood what biological processes and characteristics are most important in driving altered metabolic state in breast cancer. |
| Starting Page | P8 |
| Ending Page | P8 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://bmcproc.biomedcentral.com/track/pdf/10.1186/1753-6561-6-S3-P8?site=bmcproc.biomedcentral.com |
| PubMed reference number | 3395052 |
| Volume Number | 6 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amino Acids Biomass Cell Nucleus Gene Expression Glycolysis Habitat Mammary Neoplasms Metabolic Process, Cellular Nucleic Acids Phenotype Stroma glucose uptake |
| Content Type | Text |
| Resource Type | Article |
