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Photic induction of Fos protein in the suprachiasmatic nucleus is inhibited by the NMDA receptor antagonist MK-801
| Content Provider | Semantic Scholar |
|---|---|
| Author | Abe, Hiroshi Rusak, Benjamin Robertson, Harold A. |
| Copyright Year | 1991 |
| Abstract | Exposure of rodents to light can induce expression of a number of immediate-early genes, including c-fos, in cells of the suprachiasmatic nucleus (SCN), a dominant pacemaker in the mammalian circadian system. We examined the effects of pre-treatment with the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801, on the induction of Fos-like immunoreactivity (Fos-lir) in cells in the hamster SCN. At doses of 3 and 5 mg/kg, MK-801 treatment blocked photic induction of Fos-lir in the rostral SCN and ventrolateral portions of the caudal SCN but failed to block induction of Fos-lir in a discrete region of the dorsolateral SCN. These results suggest that photic induction of Fos-lir in most of the SCN depends on activation of an NMDA-type receptor which is sensitive to MK-801, but that Fos-lir in one portion of the SCN is induced by a mechanism which is not antagonized by MK-801. |
| Starting Page | 9 |
| Ending Page | 12 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(91)90881-S |
| PubMed reference number | 1831888 |
| Journal | Medline |
| Volume Number | 127 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409190881S |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409190881S?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2891%2990881-S |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
