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Stringent or nonstringent complete remission and prognosis in acute myeloid leukemia: a Danish population-based study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Øvlisen, Andreas Kiesbye Oest, Anders Bendtsen, Mette Dahl Bæch, John Johansen, Patricia Lynggaard, Line Stensig Mølle, Ingolf Mortensen, Thomas Bech Weber, Duruta Ertner, Gideon Schöllkopf, Claudia Thomassen, Jesper Qvist Nielsen, Ove Juul Østgård, Lene Sofie Granfeldt Bøgsted, Martin Dybkær, Karen Johnsen, Hans Erik Severinsen, Marianne T. |
| Copyright Year | 2018 |
| Abstract | Stringent complete remission (sCR) of acute myeloid leukemia is defined as normal hematopoiesis after therapy. Less sCR, including non-sCR, was introduced as insufficient blood platelet, neutrophil, or erythrocyte recovery. These latter characteristics were defined retrospectively as postremission transfusion dependency and were suggested to be of prognostic value. In the present report, we evaluated the prognostic impact of achieving sCR and non-sCR in the Danish National Acute Leukaemia Registry, including 769 patients registered with classical CR (ie, <5% blasts in the postinduction bone marrow analysis). Individual patients were classified as having sCR (n = 360; 46.8%) or non-sCR (n = 409; 53.2%) based on data from our national laboratory and transfusion databases. Survival analysis revealed that patients achieving sCR had superior overall survival (hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.10-1.64) as well as relapse-free survival (HR, 1.25; 95% CI, 1.03-1.51) compared with those with non-sCR after adjusting for covariates. Cox regression analysis regarding the impact of the stringent criteria for blood cell recovery identified these as significant and independent variables. In conclusion, this real-life register study supports the international criteria for response evaluation on prognosis and, most importantly, documents each of the 3 lineage recovery criteria as contributing independently. |
| Starting Page | 559 |
| Ending Page | 564 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://vbn.aau.dk/files/277313675/Stringent_or_nonstringent_complete_remission_and_prognosis_in_acute_myeloid_.pdf |
| PubMed reference number | 29523528v1 |
| Alternate Webpage(s) | https://doi.org/10.1182/bloodadvances.2017007393 |
| DOI | 10.1182/bloodadvances.2017007393 |
| Journal | Blood advances |
| Volume Number | 2 |
| Issue Number | 5 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute leukemia Blood Cells Blood Platelets Bone Marrow Classification Confidence Intervals Contribution Erythrocytes Forecast of outcome Hazard Ratio Hematopoiesis Leukemia, Myelocytic, Acute Overall Survival Patients Platelet Count measurement Prognosis:Find:Pt:^Patient:Nom Published Database Registration Registries childhood acute myeloid leukemia in remission emotional dependency neutrophil pediatric acute myeloblastic leukemia |
| Content Type | Text |
| Resource Type | Article |
