NDLI: Platelet factor-4 is an indicator of blood count recovery in acute myeloid leukemia patients in complete remission.

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Platelet factor-4 is an indicator of blood count recovery in acute myeloid leukemia patients in complete remission.

Content Provider	Semantic Scholar
Author	Kim, Jin Young Song, Ho-Jun Lim, Hoi-Jeong Shin, Myung-Geun Kim, Jae Seong Kim, Hyeoung-Joon Kim, Baik Yoon Lee, Seung-Won
Copyright Year	2008
Abstract	To investigate whether serum biomarkers can be used to indicate the responsiveness of acute myeloid leukemia to remission induction chemotherapy, we performed MALDI-TOF protein profile analysis of patient sera. The resulting spectra revealed a protein (or peptide) peak at m/z 7764 that varied in intensity; its intensity was much higher in samples from patients in complete remission than in those from patients with resistant disease or in samples taken prior to treatment (at the time of diagnosis). Using fractionation, trypsin digestion, MS/MS, and protein molecular weight analyses, we identified the m/z 7764 protein as platelet factor-4 (PF4). This identification was confirmed by a magnetic bead-based MALDI immunoassay. Statistical comparison of PF4 levels and platelet counts in patient sera revealed a significant positive correlation between the two variables. This study demonstrates that PF4 protein levels are a good indicator for the recovery of blood count in the complete remission of acute myeloid leukemia. The linear positive correlation curve indicates that blood count recovery of platelets to >100,000/mm(3) is equivalent to a serum PF4 recovery level of >2.492 microg/ml.
File Format	PDF HTM / HTML
DOI	10.1074/mcp.M700194-MCP200
PubMed reference number	17998245
Journal	Medline
Volume Number	7
Issue Number	2
Alternate Webpage(s)	http://www.mcponline.org/content/7/2/431.full.pdf
Alternate Webpage(s)	https://doi.org/10.1074/mcp.M700194-MCP200
Journal	Molecular & cellular proteomics : MCP
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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