NDLI: Effect of hemodilution on cerebral hemodynamics and oxygen metabolism.

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Effect of hemodilution on cerebral hemodynamics and oxygen metabolism.

Content Provider	Semantic Scholar
Author	Hino, Akihiko Ueda, Shin-Ichiro Mizukawa, N. Imahori, Yoshio Tenjin, Hiroshi
Copyright Year	1992
Abstract	BACKGROUND AND PURPOSE To evaluate the effects of hemodilution on cerebral hemodynamics and oxygen metabolism in the normal human brain, we measured regional cerebral blood flow, oxygen extraction fraction, oxygen metabolic rate, and regional cerebral blood volume in eight normal volunteers before and after hemodilution using positron emission tomography and oxygen-15-labeled gas inhalation technique. SUMMARY OF REPORT Hemodilution was accomplished by phlebotomy of 400 ml and drip infusion of 500 ml low molecular weight dextran, which reduced hematocrit from 42.5% to 37.2% and arterial oxygen content from 19.1 to 16.9 ml/dl (both p less than 0.005). It also increased mean cerebral blood flow from 45.2 to 47.7 ml/100 ml/min (p less than 0.025), but decreased tissue oxygen delivery from 8.7 to 8.0 ml/100 ml/min (p less than 0.05) and cerebral blood volume from 4.9% to 4.6% (p less than 0.025) in the overall cortical gray matter. CONCLUSIONS Our results indicate that hemodilution in the tested range does not improve oxygen transport or tissue oxygenation in the normal human brain, although it increases cerebral blood flow.
Starting Page	11
Ending Page	20
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://stroke.ahajournals.org/content/strokeaha/23/3/423.full.pdf?download=true
Alternate Webpage(s)	http://stroke.ahajournals.org/content/strokeaha/23/3/423.full.pdf
PubMed reference number	1542907v1
Volume Number	23
Issue Number	3
Journal	Stroke
Language	English
Access Restriction	Open
Subject Keyword	Cell Respiration Cerebral Blood Volume Cerebrovascular Circulation Dextrans Gray Matter Hematocrit procedure Hematological Disease Hemodynamics Heparin, Low-Molecular-Weight Milliliter per Deciliter Milliliter per Minute Oxygen content level Positron-Emission Tomography Positrons Tracer Extraction Fraction Vascular Hemostatic Disorders oxygen metabolic process oxygen transport
Content Type	Text
Resource Type	Article

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