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Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Coles, Jonathan P. Fryer, Tim D. Coleman, Martin R. Smielewski, Peter Gupta, Arun Kumar Minhas, Pawan S. Aigbirhio, Franklin I. Chatfield, Doris A. Williams, Guy B. Boniface, Simon Carpenter, T. Adrian Clark, John Connors Pickard, John D. Menon, David K. |
| Copyright Year | 2007 |
| Abstract | OBJECTIVE To determine whether hyperventilation exacerbates cerebral ischemia and compromises oxygen metabolism (CMRO2) following closed head injury. DESIGN A prospective interventional study. SETTING A specialist neurocritical care unit. PATIENTS Ten healthy volunteers and 30 patients within 10 days of closed head injury. INTERVENTIONS Subjects underwent oxygen-15 positron emission tomography imaging of cerebral blood flow, cerebral blood volume, CMRO2, and oxygen extraction fraction. In patients, positron emission tomography studies, somatosensory evoked potentials, and jugular venous saturation (SjO2) measurements were obtained at Paco2 levels of 36+/-3 and 29+/-2 torr. MEASUREMENTS AND MAIN RESULTS We estimated the volume of ischemic brain and examined the efficiency of coupling between oxygen delivery and utilization using the sd of the oxygen extraction fraction distribution. We correlated CMRO2 to cerebral electrophysiology and examined the effects of hyperventilation on the amplitude of the cortical somatosensory evoked potential response. Patients showed higher ischemic brain volume than controls (17+/-22 vs. 2+/-3 mL; p |
| Starting Page | 247 |
| Ending Page | 252 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.safar.pitt.edu/archive/content/grant/jc/2007/0202%20Alexander.pdf |
| Alternate Webpage(s) | https://www.safetylit.org/citations/ild_request_form.php?article_id=citjournalarticle_369863_38 |
| PubMed reference number | 17205016v1 |
| Volume Number | 35 |
| Issue Number | 2 |
| Journal | Critical care medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acoustic Evoked Brain Stem Potentials Arabic numeral 0 Brain Injuries Cell Respiration Cerebral Blood Volume Cerebral Ischemia Cerebrovascular Circulation Closed head injuries Craniocerebral Trauma Electrophysiology (science) MATCHING Patients Positron-Emission Tomography Positrons Somatosensory Evoked Potentials Tracer Extraction Fraction X-Ray Computed Tomography oxygen metabolic process torr |
| Content Type | Text |
| Resource Type | Article |
