NDLI: Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease

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Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease

Content Provider	Semantic Scholar
Author	Volc-Platzer, Beatrix Majdic, Otto Knapp, Walter E. Wolff, K. Hinterberger, Wolfgang Lechner, Klaus Stingl, Georg
Copyright Year	1984
Abstract	As opposed to normal human skin where HLA-DR expression is restricted to the Langerhans cell (LC) population, HLA-DR, but not HLA-DS antigens can be readily detected on keratinocytes (KC) in certain disease states, i.e., cutaneous T cell lymphoma (CTCL), graft-vs-host disease (GVHD), and lichen planus (LP). To clarify the cellular origin of KC-bound HLA-DR antigens, we used a monoclonal antibody directed against determinants solely expressed on the cytoplasmic HLA-DR gamma chain (VIC-Y1) and observed that, by immunofluorescence, KC displaying HLA-DR alpha/beta complexes on their surface uniformly displayed cytoplasmic VIC-Y1 reactivity. In view of the crucial role of the gamma chain for HLA-DR biosynthesis, we conclude that HLA-DR antigens on KC are actively synthesized by these cells.
Starting Page	1784
Ending Page	1789
Page Count	6
File Format	PDF HTM / HTML
PubMed reference number	6202820
Volume Number	159
Journal	The Journal of experimental medicine
Alternate Webpage(s)	http://ftp.ncbi.nlm.nih.gov/pub/pmc/a3/cf/je15961784.PMC2187314.pdf
Language	English
Access Restriction	Open
Subject Keyword	Anabolism Graft versus host disease prophylaxis/therapy HIV Antigens HLA-DQ Antigens HLA-DR Antigens Histocompatibility Antigens Class II Langerhans cell Lichen Planus Lymphoma, T-Cell, Cutaneous Monoclonal Antibodies T-Cell Lymphoma Transplanted tissue ifosfamide/lomustine/vinblastine keratinocyte
Content Type	Text
Resource Type	Article

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