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Acute graft versus host disease due to T lymphocytes recognizing a single HLA-DPB1*0501 mismatch.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Gaschet, Joëlle Lim, Annick Liem, L. H. Vivien, Régine Hallet, M. M. Even, Jos Goulmy, Els Bonneville, Marc Milpied, Nöel Vié, Henri |
| Copyright Year | 1996 |
| Abstract | Analysis of a large number of unrelated bone marrow transplantations (BMT) has shown that HLA-DP incompatibility did not detectably influence the risk for acute graft-versus-host disease (aGVHD). Accordingly, it was proposed that HLA-DP determinants did not function as transplantation antigens in the same way as HLA-A, -B, or -DR. We have previously shown that HLA-DP (as well as HLA-A, -B, -DQ, or -DR)-specific T cells could be isolated from skin biopsies of patients who developed an aGVHD after semiallogeneic BMT. Nevertheless, whether a single HLA-DP mismatched allele could induce a detectable allo-specific reaction in vivo after BMT remained to be established. To directly address this issue we studied one patient who presented aGVHD after receiving purified CD34+ bone marrow (BM) cells from an unrelated donor with a single HLA-DP mismatch in the GVHD direction. To characterize the immunological events associated with GVHD, we analyzed the peripheral T cell repertoire, the T cell receptor Vbeta diversity, and the specificity of T cells invading a skin biopsy at the onset of GVHD. Our results demonstrated that a large fraction of skin-infiltrating lymphocytes, which expressed diverse T cell receptors, were reactive against this single HLA-DPB1 *0501 mismatch and consequently that a single HLA-DP mismatch between BM donor and recipient can activate a strong T cell response in vivo. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jci.org/articles/view/118753/version/1/pdf/render |
| Alternate Webpage(s) | http://dm5migu4zj3pb.cloudfront.net/manuscripts/118000/118753/JCI96118753.pdf |
| Alternate Webpage(s) | https://openaccess.leidenuniv.nl/bitstream/handle/1887/2075/304_151.pdf;sequence=1 |
| PubMed reference number | 8690780v1 |
| Volume Number | 98 |
| Issue Number | 1 |
| Journal | The Journal of clinical investigation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activation action Allopurinol Biopsy of skin procedure Bone Marrow Transplantation Graft versus host disease prophylaxis/therapy HLA Antigens HLA-A Antigens HLA-DP Antigens HLA-DQ Antigens Histocompatibility Antigens Infiltration Leukemia, B-Cell Major Histocompatibility Complex, Class II, DP Beta 1 Patients Receptors, Cell Surface T-Lymphocyte Transplanted tissue |
| Content Type | Text |
| Resource Type | Article |
