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Primary cutaneous CD8+ and CD56+ T-cell lymphomas express HLA-G and killer-cell inhibitory ligand, ILT2.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Urosevic, Mirjana Kamarashev, Jivko Burg, Guenter Dummer, Reinhard |
| Copyright Year | 2004 |
| Abstract | Primary cutaneous lymphomas constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Cutaneous T-cell lymphomas of the cytotoxic phenotype, including CD8+ and CD56+ lymphomas, are rare entities that have only been recently recognized and characterized. These lymphomas often show an aggressive clinical course. We investigated the expression of human leukocyte antigen G (HLA-G) and interleukin 10 (IL-10) in conjunction with expression of HLA-G killer-cell inhibitory receptor ligand immunoglobulin-like transcript 2 (ILT2) in 3 CD56+CD4+ and 4 CD8+ cutaneous T-cell lymphomas. HLA-G expression was detected in 2 of 3 lymphomas of the CD56+CD4+ type and in all lymphomas of CD8+ type. It is of note that CD56+CD4+ lymphomas displayed stronger HLA-G reactivity. The expression of IL-10 matched the expression of HLA-G. Together with the expression of IL-10, HLA-G might be one of the factors accounting for the evasion of immunosurveillance, thus contributing to aggressive phenotype of these lymphoma entities. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/early/2003/10/30/blood-2003-10-3372.full.pdf?sso-checked=true |
| PubMed reference number | 14592815v1 |
| Volume Number | 103 |
| Issue Number | 5 |
| Journal | Blood |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CD56 Antigens Clone Contribution Cutaneous lymphoma HLA Antigens HLA Complex HLA-DQ Antigens Interleukin-10 Interleukins LILRB1 protein, human Leukocytes Ligands Monitoring, Immunologic T-Cell Lymphoma Transcript |
| Content Type | Text |
| Resource Type | Article |
