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How Do We Interpret the Presence of Donor-Specific Antibodies When There Is No Rejection?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Crew, Russell J. Fajardo, Melissa |
| Copyright Year | 2019 |
| Abstract | P retransplant measurement of donor-specific human leukocyte antigen (HLA) antibodies (DSAs) in kidney transplantation has been a mainstay of immunologic risk assessment since the 1970s, starting with the original T-cell Cytotoxic Crossmatch. Testing has become progressively more sensitive through modifications in the assay and the addition of flow cytometry. The newest iteration of antibody assessment involves mixing patient sera with HLA peptides attached to polystyrene beads and measuring the antibody binding using the Luminex platform. This technique provides detailed information about breadth of anti-HLA antibodies that could lead to rejection, as well as semiquantitative information about the quantity of each antibody specificity. As experience in the anti-HLA Luminex testing has grown, it has become clear that not all antibodies are created equal. |
| Starting Page | 1040 |
| Ending Page | 1042 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.ekir.2019.05.008 |
| PubMed reference number | 31440694 |
| Journal | Medline |
| Volume Number | 4 |
| Alternate Webpage(s) | https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/4e/main.PMC6698305.pdf |
| Journal | Kidney international reports |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
