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Focal C4d+ in Renal Allografts Is Associated with the Presence of Donor-Specific Antibodies and Decreased Allograft Survival
| Content Provider | Scilit |
|---|---|
| Author | Kedainis, R. L. Koch, M. J. Brennan, D. C. Liapis, H. |
| Copyright Year | 2009 |
| Description | Journal: American Journal of Transplantation Diffuse peritubular capillary C4d deposition in renal allograft biopsies is associated with donor‐specific antibodies (DSA) and graft failure. The significance of focal C4d+ is unclear. We reviewed 368 biopsies from 301 patients performed for renal dysfunction or proteinuria over 5 years. Diffuse C4d+, focal C4d+ and C4d‐ detected by immunofluorescence occurred in 9.5%, 20.9% and 69.4% of biopsies, respectively. Patients were similar in gender, age, cause of renal disease, donor source, HLA mismatch, serum creatinine at baseline and interval from transplantation to biopsy. Diffuse and focal C4d+ were associated with acute cellular rejection (p < 0.001). Transplant glomerulopathy was associated with diffuse C4d+. DSA at the time of biopsy, were positive in 79.3% of diffusely C4d+ patients, 68.8% of those with focal C4d+ (p = 0.27) and 9.9% of patients with C4d‐ (p < 0.001, compared to either the focal or diffuse groups, respectively). Allograft survival at 40 months was lower in diffuse C4d+ compared to the C4d‐ group (p = 0.014), but not when compared to the focal C4d+ group. There was a clear trend toward worse graft survival in patients with focal C4d+ in this time interval, but focal C4d+ compared to both diffuse C4d+ and C4d‐groups was not statistically significant (p = 0.08). |
| Related Links | http://europepmc.org/articles/pmc2730653?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730653/pdf https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1600-6143.2009.02555.x |
| Ending Page | 819 |
| Page Count | 8 |
| Starting Page | 812 |
| e-ISSN | 16006143 |
| DOI | 10.1111/j.1600-6143.2009.02555.x |
| Journal | American Journal of Transplantation |
| Issue Number | 4 |
| Volume Number | 9 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2009-03-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: American Journal of Transplantation Donor‐specific Antibodies |
| Content Type | Text |
| Resource Type | Article |
