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Synthesis and biological activity of novel 2,5-disubstituted-1,3,4-oxadiazoles
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shailaja, Myadaraboina Anitha, Mandala Manjula, Arumugam Rao, Bommena Vittal |
| Copyright Year | 2010 |
| Abstract | A new and previously unrcported molecular framework of 1,3,4-oxadiazoles incorporating halo pyridines has been synthesised. The derivatives are synthesised starting from substituted pyridinyloxy benzaldehydes, by converting them in to corresponding arylidene hydrazides followed by chloramine-T oxidation to the title compounds. The 2,5-disubstituted 1,3,4-oxadiazole derivatives are tested for antimicrobial activity. Many compounds showed high degree of activity against Staphylococus aureus and Escherichia coli bacteria at 250 μg/mL concentration. |
| Starting Page | 1088 |
| Ending Page | 1097 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Volume Number | 49 |
| Alternate Webpage(s) | http://nopr.niscair.res.in/bitstream/123456789/10080/1/IJCB%2049B(8)%201088-1097.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |