NDLI: A Novel Series of 2,5-Disubstituted 1,3,4-oxadiazoles: Synthesis and SAR Study for their Anticonvulsant Activity

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A Novel Series of 2,5-Disubstituted 1,3,4-oxadiazoles: Synthesis and SAR Study for their Anticonvulsant Activity

Content Provider	Scilit
Author	Rajak, Harish Singour, Pradeep Kharya, Murli Dhar Mishra, Pradeep
Copyright Year	2011
Description	Journal: Chemical Biology & Drug Design In search for a better anticonvulsant drug and the importance of semicarbazones and 2,5-disubstituted 1,3,4-oxadiazoles as anticonvulsant pharmacophore, a series of novel substituted semicarbazones were designed, synthesized, and evaluated for their anticonvulsant activity. The chemical structures of the synthesized molecules were confirmed by elemental and spectral (IR, (1) H NMR, (13) C NMR and MS) analysis. The anticonvulsant activities of the compounds were investigated using maximal electroshock seizure and subcutaneous pentylenetetrazole (scPTZ) models. Efforts were also made to establish structure-activity relationships among synthesized compounds. The results of the present study validated that the pharmacophore model with four binding sites is essential for anticonvulsant activity.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2010.01066.x/pdf
Ending Page	158
Page Count	7
Starting Page	152
e-ISSN	17470285
DOI	10.1111/j.1747-0285.2010.01066.x
Journal	Chemical Biology & Drug Design
Issue Number	2
Volume Number	77
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2011-01-25
Access Restriction	Open
Subject Keyword	Journal: Chemical Biology & Drug Design Medicinal Chemistry
Content Type	Text
Resource Type	Article

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