NDLI: Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

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Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10

Content Provider	Semantic Scholar
Author	Hammad, Hamida Vanderkerken, Matthias Pouliot, Philippe Deswarte, Kim Toussaint, Wendy Vergote, Karl Vandersarren, Lana Janssens, Sophie Ramou, Ioanna Savvides, Savvas N. Haigh, Jody J. Hendriks, Rudi Kopf, Manfred Craessaerts, Katleen Strooper, Bart De Kearney, John F. Conrad, Daniel H. Lambrecht, Bart N.
Copyright Year	2017
Abstract	Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown how these pathways are related. We generated Taok3−/− mice, lacking the serine/threonine kinase Taok3, and found cell-intrinsic defects in the development of MZB but not FoB cells. Type 1 transitional (T1) B cells required Taok3 to rapidly respond to ligation by the Notch ligand Delta-like 1. BCR ligation by endogenous or exogenous ligands induced the surface expression of the metalloproteinase ADAM10 on T1 B cells in a Taok3-dependent manner. T1 B cells expressing surface ADAM10 were committed to becoming MZB cells in vivo, whereas T1 B cells lacking expression of ADAM10 were not. Thus, during positive selection in the spleen, BCR signaling causes immature T1 B cells to become receptive to Notch ligands via Taok3-mediated surface expression of ADAM10.
Starting Page	313
Ending Page	320
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1038/ni.3657
Alternate Webpage(s)	http://discovery.ucl.ac.uk/1541553/1/De%20Strooper_Hammad%20et%20al_Nature%20immunol%20edited%20final%20version%2025112016.pdf
PubMed reference number	28068307
Alternate Webpage(s)	https://doi.org/10.1038/ni.3657
Journal	Medline
Volume Number	18
Journal	Nature Immunology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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