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CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Yu Zhu, Gaizhi Xiao, He Liu, Xiaoling Han, Gencheng Chen, Guojiang Hou, Chunmei Shen, Beifen Li, Yan Ma, Ning Wang, Renxi |
| Copyright Year | 2017 |
| Description | Journal: Journal of Cellular and Molecular Medicine As the first line of defence, marginal zone (MZ) B cells play principal roles in clearing blood‐borne pathogens during infection and are over‐primed in autoimmune diseases. However, the basic mechanisms underlying MZ B‐cell development are still unclear. We found here that CD19 deficiency blocked the differentiation of marginal zone precursors (MZP) to MZ B cells, whereas CD19 expression in CD19‐deficient MZP rescues MZ B‐cell generation. Furthermore, CD19 regulates Notch2 cleavage by up‐regulating ADAM28 expression in MZP. Finally, we found that CD19 suppressed Foxo1 expression to promote ADAM28 expression in MZP. These results suggest that CD19 controls the differentiation of MZP to MZ B cells by regulating ADAM28‐mediated Notch2 cleavage. Thus, we demonstrated the basic mechanisms underlying the differentiation of MZP to MZ B cells. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706524/pdf |
| Ending Page | 3669 |
| Page Count | 12 |
| Starting Page | 3658 |
| e-ISSN | 15824934 |
| DOI | 10.1111/jcmm.13276 |
| Journal | Journal of Cellular and Molecular Medicine |
| Issue Number | 12 |
| Volume Number | 21 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-07-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Cellular and Molecular Medicine Marginal Zone Precursors Mz B Cells |
| Content Type | Text |
| Resource Type | Article |
