Loading...
Please wait, while we are loading the content...
Meta-analysis of Trials Comparing Drug-eluting Stents with Bare Metal Stents : Safety and Efficacy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rayatzadeh, Hussein Khoshdel, Ali Reza Chitsaz, Sam Meysamie, Ali Pasha Bagheri, Jamshid |
| Copyright Year | 2016 |
| Abstract | Background: Effects of drug-eluting stents (DESs) on clinical outcomes as well as stent thrombosis are still under debate. Methods: Our meta-analysis included 26 randomized trials comparing DESs with bare metal stents (BMSs). The endpoints analyzed were all-cause mortality, cardiac death, myocardial infarction (MI), target lesion (TLR) and target vessel (TVR) revascularization, restenosis, and stent thrombosis. Results: In-stent (Risk Ratio = 0.23 [95% confidence interval: 0.17 0.32]) and in-segment restenosis (RR = 0.31 [0.24 0.40]) significantly reduced in patients with DESs compared with BMSs. Nonetheless, the all-cause mortality (RR = 0.98 [0.79 1.21]) and cardiac death (RR = 0.93 [0.71 1.21]) were not significantly different for patients receiving DESs compared with BMSs. DESs versus BMSs resulted in a significant decrease in MI (RR = 0.79 [0.67 0.93]), TLR (RR = Systematic Review Article Rayatzadeh et al.; BJMMR, 14(4): 1-19, 2016; Article no.BJMMR.24622 2 0.33 [0.29 0.38]), and TVR (RR = 0.47 [0.42 0.52]). Stent thrombosis incidence that did not differ in DESs versus BMSs until the first year after implantation, showed an upward trend in DESs compared with BMSs from then on (RR = 3.09 [1.37 6.99]). Conclusions: The use of DESs versus BMSs led to benefits in angiographic restenosis and clinical outcomes. However, higher incidence of long-term stent thrombosis warrants their cautious usage in patients at high-risk of stent thrombosis. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.journalrepository.org/media/journals/BJMMR_12/2016/Mar/Khoshdel1442016BJMMR24622.pdf |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bare machine Battery management system Cardiac Death Confidence Intervals Diethylstilbestrol Drug-Eluting Stents Incidence matrix Ion implantation Medicine Metal-on-Metal Implant Bearings Myocardial Infarction Patients Power (Psychology) Randomized algorithm Rapid Refresh Rule (guideline) SCSI Enclosure Services Science Stent Device Component Stent, device Systematic review Thrombosis benefit restenosis revascularization |
| Content Type | Text |
| Resource Type | Article |
