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Meta-analysis comparing drug-eluting stents with bare metal stents.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Katritsis, Demosthenes G. Karvouni, Evangelia Ioannidis, John P. A. |
| Copyright Year | 2005 |
| Abstract | We performed a meta-analysis of 10 randomized trials of 5,066 patients with 6 to 12 months of follow-up. The summary risk differences excluded any major differences between the 2 types of stents for death (0.12%, 95% confidence interval [CI] -0.34% to 0.58%, p = 0.60) and overall myocardial infarction (0.04%, 95% CI -0.72% to 0.81%, p = 0.91). There was a modest increase in the risk of Q-wave myocardial infarction with drug-eluting stents (0.36%, 95% CI -0.04% to 0.77%, p = 0.080) but no difference in non-Q-wave myocardial infarction (-0.26%, 95% CI -0.95% to 0.43%, p = 0.47). The trend for increased risk of Q-wave myocardial infarction was seen for paclitaxel and sirolimus stents (risk differences 0.28% and 0.58%, respectively). Drug-eluting stents also had a nonsignificant trend for higher risk of thrombosis (0.29%, 95% CI -0.08% to 0.66%, p = 0.13). We conclude that sirolimus- and paclitaxel-eluting stents are equivalent to bare-metal stents in terms of mortality and overall myocardial infarction risk for the first year of follow-up; the meta-analysis excludes with considerable confidence the presence of large, clinically relevant differences for these outcomes. |
| Starting Page | 58 |
| Ending Page | 67 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.crd.york.ac.uk/CRDWeb/PrintPDF.php?AccessionNumber=12005009598&Copyright=Database+of+Abstracts+of+Reviews+of+Effects+(DARE)%3Cbr+/%3EProduced+by+the+Centre+for+Reviews+and+Dissemination+%3Cbr+/%3ECopyright+%26copy%3B+2016+University+of+York%3Cbr+/%3E |
| PubMed reference number | 15721109v1 |
| Volume Number | 95 |
| Issue Number | 5 |
| Journal | The American journal of cardiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cessation of life Confidence Intervals Drug-Eluting Stents Exclusion Follow-Up Report Myocardial Infarction Paclitaxel Patients Sirolimus Stent, device Thrombosis |
| Content Type | Text |
| Resource Type | Article |
