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Effect of length and diameter of drug-eluting stents versus bare-metal stents on late outcomes.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Applegate, R. Joseph Sacrinty, Matthew T. Kutcher, Michael A. Santos, Ricarda Maria Dos Gandhi, Shantilal K. Little, William Campbell |
| Copyright Year | 2009 |
| Abstract | BACKGROUND The risk of restenosis and other adverse cardiac events with bare-metal stents (BMS) is increased with smaller stent diameters and longer stent lengths. Drug-eluting stents (DES) may reduce this effect in select patients; however, whether this benefit occurs in high-risk lesions and patients in routine practice is not clear. METHODS AND RESULTS Clinical outcomes (target-vessel revascularization [TVR], stent thrombosis, nonfatal myocardial infarction [MI], and cardiac death) at 2 years stratified by stented length and diameter were compared in 949 consecutive patients who received BMS and 1236 consecutive and comparable patients who received DES for single lesions. The longest tertile of BMS (>23 mm) was associated with increased hazard of TVR, ST, and nonfatal MI or death compared with shorter tertiles of BMS, which was abolished by DES. DES compared with BMS was independently associated with a lower hazard of TVR (HR, 0.34 [0.20 to 0.58]) and nonfatal MI or death (HR, 0.60 [0.39 to 0.92]) in the longest length tertile (>23 mm). No clear association of stented tertile diameter and clinical outcomes for either stent type was observed. However, DES compared with BMS was independently associated with a lower hazard of TVR for all diameter tertiles, and a lower hazard of nonfatal MI or death (0.66 [0.44 to 0.99]) in the largest diameter tertile (>3.4 mm). CONCLUSIONS Independent of adverse patient and lesion characteristics, DES demonstrated significantly lower hazard of TVR and nonfatal MI or death at 2 years compared with BMS within the longest stented lengths (>23 mm) and largest diameters (>3.4 mm). |
| Starting Page | 35 |
| Ending Page | 42 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circinterventions.ahajournals.org/content/circcvint/2/1/35.full.pdf?download=true |
| PubMed reference number | 20031691v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/CIRCINTERVENTIONS.108.805630 |
| DOI | 10.1161/circinterventions.108.805630 |
| Journal | Circulation. Cardiovascular interventions |
| Volume Number | 2 |
| Issue Number | 1 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Blood Vessel Tissue Cardiac Death Cerebral Revascularization Cessation of life Diameter (qualifier value) Drug-Eluting Stents Myocardial Infarction Patients Small Stent Device Component Stent, device Thrombosis restenosis |
| Content Type | Text |
| Resource Type | Article |
