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Offset-sparsity decomposition for automated enhancement of color microscopic image of stained specimen in histopathology.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kopriva, Ivica Hadzija, Marijana Popovic Hadzija, Mirko Aralica, Gorana |
| Copyright Year | 2015 |
| Abstract | We propose an offset-sparsity decomposition method for the enhancement of a color microscopic image of a stained specimen. The method decomposes vectorized spectral images into offset terms and sparse terms. A sparse term represents an enhanced image, and an offset term represents a "shadow." The related optimization problem is solved by computational improvement of the accelerated proximal gradient method used initially to solve the related rank-sparsity decomposition problem. Removal of an image-adapted color offset yields an enhanced image with improved colorimetric differences among the histological structures. This is verified by a no-reference colorfulness measure estimated from 35 specimens of the human liver, 1 specimen of the mouse liver stained with hematoxylin and eosin, 6 specimens of the mouse liver stained with Sudan III, and 3 specimens of the human liver stained with the anti-CD34 monoclonal antibody. The colorimetric difference improves on average by 43.86% with a 99% confidence interval (CI) of [35.35%, 51.62%]. Furthermore, according to the mean opinion score, estimated on the basis of the evaluations of five pathologists, images enhanced by the proposed method exhibit an average quality improvement of 16.60% with a 99% CI of [10.46%, 22.73%]. |
| Starting Page | 76012 |
| Ending Page | 76012 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://bib.irb.hr/datoteka/771902.Kopriva_Hadzija_Hadzija_Aralica_JBO_2015_Accepted.pdf |
| PubMed reference number | 26220370v1 |
| Alternate Webpage(s) | https://doi.org/10.1117/1.JBO.20.7.076012 |
| DOI | 10.1117/1.JBO.20.7.076012 |
| Journal | Journal of biomedical optics |
| Volume Number | 20 |
| Issue Number | 7 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CDISC SEND Biospecimens Terminology Confidence Intervals Eosine Yellowish Evaluation Gradient Hematoxylin and eosin stain method Histopathology Monoclonal Antibodies Name Ninety Nine Optic Nerve Glioma, Childhood Specimen Sudan III |
| Content Type | Text |
| Resource Type | Article |
