The route of metastatic vertebral tumors extending to the adjacent vertebral body: a histological study

Content Provider	Semantic Scholar
Author	Sasagawa, Takeshi Kawahara, Norio Murakami, Hideki Demura, Satoru Yoshioka, Katsuhito Yamaguchi, Tomotaka Tsuchiya, Hiroyuki Tomita, Kristen
Copyright Year	2011
Abstract	BackgroundEach vertebra can be regarded as a compartment surrounded by several anatomically characterized barriers. However, in some cases tumors extend beyond these barriers. The route of vertical extension to the adjacent vertebrae is unclear. The extent of vertical extension of a metastatic spinal tumor is important in making the preoperative decision regarding the cranio-caudal surgical margin. The objective of this study was to investigate the route of vertical extension of metastatic vertebral tumors.MethodsWe examined 20 en bloc resected metastatic vertebral bodies in which the tumors had extended outside the vertebral body. Five to eight sagittal sections including the pedicle, and the lateral and central parts of the PLL were prepared from each resected specimen. The sections were stained with hematoxylin and eosin, and elastica van Gieson. Histological examination focused on the routes of the vertical extension of the tumor at each barrier tissue and the degree of tumor extension along each route.ResultsVertical extension of the tumor was observed at the ALL in 6 cases, at the central part of the PLL in 14 cases, at the lateral part of the PLL in 20 cases, at the cartilaginous endplate in 3 cases, and at the periosteum on the lateral side of vertebral body in 7 cases. The tumor had extended the farthest at the lateral part of the PLL in 18 cases, at the lateral side of the vertebral body in 1 case, and through the disc in 1 case.ConclusionsMetastatic vertebral tumors most commonly extend vertically at the lateral part of the PLL. The lateral part of the PLL is raised by the tumor, which extends between the PLL and the posterior aspect of the disc.
Starting Page	46
Ending Page	51
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dspace.lib.kanazawa-u.ac.jp/dspace/bitstream/2297/29289/1/ME-PR-SASAGAWA-T-203.pdf
PubMed reference number	21360258v1
Alternate Webpage(s)	https://doi.org/10.1007/s00776-011-0031-9
DOI	10.1007/s00776-011-0031-9
Journal	Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
Volume Number	16
Issue Number	2
Language	English
Access Restriction	Open
Subject Keyword	Anatomical compartments Bone structure of spine CDISC SEND Biospecimens Terminology Cartilage Caudal Ellis-Van Creveld Syndrome Eosine Yellowish Hematoxylin and eosin stain method Hyperostosis, Diffuse Idiopathic Skeletal Part Dosing Unit Prolymphocytic Leukemia Sagittal plane Spinal Cord Neoplasms Surgical margins posterior lateral line system development
Content Type	Text
Resource Type	Article