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Morphobiochemical diagnosis of acute trabecular microfractures using gamma correction Tc-99m HDP pinhole bone scan with histopathological verification
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bahk, Yong-Whee Hwang, Seok-Ha Lee, U-Young Chung, Yong-An Jung, Joo-Young Jeong, Hyeonseok S. |
| Copyright Year | 2017 |
| Abstract | We prospectively performed gamma correction pinhole bone scan (GCPBS) and histopathologic verification study to make simultaneous morphobiochemical diagnosis of trabecular microfractures (TMF) occurred in the femoral head as a part of femoral neck fracture.Materials consisted of surgical specimens of the femoral head in 6 consecutive patients. The specimens were imaged using Tc-99m hydroxymethylene diphosphonate (HDP) pinhole scan and processed by the gamma correction. After cleansing with 10% formalin solution, injured specimen surface was observed using a surgical microscope to record TMF. Morphological findings shown in the photograph, naive pinhole bone scan, GCPBS, and hematoxylin-eosin (H&E) stain of the specimen were reciprocally correlated for histological verification and the usefulness of suppression and enhancement of Tc-99m HDP uptake was biochemically investigated in TMF and edema and hemorrhage using gamma correction.On the one hand, GCPBS was able to depict the calcifying calluses in TMF with enhanced Tc-99m HDP uptake. They were pinpointed, speckled, round, ovoid, rod-like, geographic, and crushed in shape. The smallest callus measured was 0.23 mm in this series. On the other hand, GCPBS biochemically was able to discern the calluses with enhanced high Tc-99m HDP uptake from the normal and edema dipped and hemorrhage irritated trabeculae with washed out uptake.Morphobiochemically, GCPBS can clearly depict microfractures in the femoral head produced by femoral neck fracture. It discerns the microcalluses with enhanced Tc-99m HDP uptake from the intact and edema dipped and hemorrhage irritated trabeculae with suppressed washed out Tc-99m HDP uptake. Both conventional pinhole bone scan and gamma correction are useful imaging means to specifically diagnose the microcalluses naturally formed in TMF. |
| Starting Page | 699 |
| Ending Page | 699 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 29137027v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/MD.0000000000008419 |
| DOI | 10.1097/MD.0000000000008419 |
| Journal | Medicine |
| Volume Number | 96 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Bone callus CDISC SEND Biospecimens Terminology Cancellous Bone Diphosphonates Edema Eosine Yellowish Femoral Neck Fractures Formalin Head of femur Hematoxylin and eosin stain method Hemorrhage Histopathology Interferon Type II MICROSCOPE, SURGICAL Microscope Device Component Patients Radioisotope scan of bone Skin callus Specimen Stains Structure of neck of femur Technetium Tc 99m Medronate Technetium Tc 99m Sestamibi Verification of Theories |
| Content Type | Text |
| Resource Type | Article |
