NDLI: Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy

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Infliximab Trough Levels and Quality of Life in Patients with Inflammatory Bowel Disease in Maintenance Therapy

Content Provider	Semantic Scholar
Author	Parra, Rogério S. Feitosa, Marley Ribeiro Ribeiro, Leticia Catarino Castro, Lais De Abreu Rocha, José Joaquim Ribeiro Féres, Omar
Copyright Year	2018
Abstract	Objective Investigate the association between infliximab trough levels and quality of life in inflammatory bowel disease patients in maintenance therapy. Methods We carried out a transversal study with inflammatory bowel disease patients in infliximab maintenance therapy. Infliximab trough levels were determined using a quantitative rapid test. Disease activity indices (partial Mayo Score and Harvey-Bradshaw Index) and endoscopic scores (endoscopic Mayo Score or Simple Endoscopic Score in Crohn's disease) were obtained. Quality of life was assessed using the Inflammatory Bowel Disease Questionnaire (IBDQ). Results Seventy-one consecutive subjects were included in the study (55 with Crohn's disease and 16 with ulcerative colitis). Drug levels were considered satisfactory (≥3 μg/mL) in 28 patients (39.4%) and unsatisfactory (<3 μg/mL) in 43 (60.6%). Satisfactory trough levels were associated with higher rates of clinical remission and mucosal healing. Higher trough levels were also associated with improved IBDQ scores, particularly regarding bowel symptoms, systemic function, and social function. Conclusion Satisfactory trough levels of infliximab were associated with higher rates of clinical remission, mucosal healing, and improved quality of life in inflammatory bowel disease patients on maintenance therapy.
Starting Page	55
Ending Page	61
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://downloads.hindawi.com/journals/grp/2018/1952086.pdf
PubMed reference number	5964568
Alternate Webpage(s)	https://doi.org/10.1155/2018/1952086
DOI	10.1155/2018/1952086
Journal	Gastroenterology research and practice
Volume Number	2018
Language	English
Access Restriction	Open
Subject Keyword	Crohn Disease Inflammatory Bowel Diseases Intestinal Diseases Intestines Mucous Membrane Patients Ulcer Ulcerative Colitis infliximab
Content Type	Text
Resource Type	Article

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