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Lactosylceramide in inflammatory bowel disease: a biochemical study.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stevens, Cathy Oberholzer, V. G. Walker-Smith, John A. Phillips, Alan D. |
| Copyright Year | 1988 |
| Abstract | A simple technique for isolating lipids from small pieces of tissue was applied to mucosal biopsies and samples of resected intestine from patients with inflammatory bowel disease. Scanning densitometry of two dimensional chromatograms showed increased concentrations of the membrane associated glycosphingolipid lactosylceramide in Crohn's disease, on comparison with ulcerative colitis (p less than 0.01), or controls (p less than 0.01). This indicates either that normal glycosphingolipid metabolism is altered, or that a novel source of lactosylceramide is present in the inflamed mucosa of patients with Crohn's disease. |
| Starting Page | A560 |
| Ending Page | A560 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://gut.bmj.com/content/gutjnl/29/5/580.full.pdf |
| PubMed reference number | 3396945v1 |
| Volume Number | 29 |
| Issue Number | 5 |
| Journal | Gut |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biopsy CDw17 antigen Crohn Disease Densitometry Glycosphingolipids ISOLATE COMPOUND Intestinal Diseases Intestinal Wall Tissue Intestines Mucous Membrane Patients Tissue membrane Ulcer Ulcerative Colitis glycosphingolipid metabolic process |
| Content Type | Text |
| Resource Type | Article |
