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Effect of pyridoxal 5'-phosphate on the 1,25-dihydroxyvitamin D3 receptor system.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shimura, Fujio Watanabe, Midori Shimura, Junko Hosoya, Norimasa |
| Copyright Year | 1983 |
| Abstract | The effect of pyridoxal 5'-phosphate on the 1,25-dihydroxyvitamin D3 receptor system has been studied by using pig intestinal chromatin. Pyridoxal 5'-phosphate did not affect the binding of 1,25-dihydroxyvitamin D3 to its receptor extracted from chromatin with hypertonic KCl, although in the presence of pyridoxal 5'-phosphate 1,25-dihydroxyvitamin D3-receptor complexes were not readily precipitated with polyethylene glycol. In contrast, pyridoxal 5'-phosphate showed a potency to dissociate the 1,25-dihydroxyvitamin D3 receptor from chromatin in a dose-dependent manner. A low concentration of pyridoxal 5'-phosphate was as effective as hypertonic KCl in dissociating the receptor from chromatin, while pyridoxine, p-nitrophenyl phosphate, or inorganic phosphate was much less effective. These observations suggest the inhibitory effect of pyridoxal 5'-phosphate on the recognition of 1,25-dihydroxyvitamin D3 by its receptor system. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/jnsv1973/29/5/29_5_533/_pdf/-char/en |
| PubMed reference number | 6319648v1 |
| Volume Number | 29 |
| Issue Number | 5 |
| Journal | Journal of nutritional science and vitaminology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Calcitriol Carbamoyl-Phosphate Synthase I Deficiency Disease Phosphate measurement Polyethylene Glycols Potassium Chloride Pyridoxal Phosphate inorganic phosphate pyridoxine |
| Content Type | Text |
| Resource Type | Article |
