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Plasma Pyridoxal 5´-Phosphate Level in Children with Intractable and Controlled Epilepsy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pirzadeh, Zahra Ghofrani, Mohammad B. Mollamohammadi, Mohsen |
| Copyright Year | 2017 |
| Abstract | OBJECTIVE Intractable epilepsy is a serious neurologic problem with different etiologies. Decreased levels of pyridoxal phosphate in cerebral spinal fluid of patients with intractable epilepsy due to pyridoxine dependency epilepsy are reported. The aim of this study was to compare plasma pyridoxal 5´-phosphate level in patients with intractable and controlled epilepsy. MATERIALS & METHODS This cross- sectional analytic study included 66 epileptic children, 33 patients with controlled and 33 patients with intractable epilepsy, after neonatal period up to 15 yr old of age. Thirty-three patients with intractable epilepsy (10- 162 months) and 33 patients with controlled epilepsy (14-173 months) were enrolled. The study was conducted in Pediatric Neurology Clinic of Mofid Children Hospital, Tehran, Iran from January 2010 to December 2010. Patients' clinical manifestations, laboratory and neuroimaging findings were collected. Non-fasting plasma 5´- pyridoxal phosphate levels of these subjects were assessed by high-pressure liquid chromatography. RESULTS Mean plasma 5´- pyridoxal phosphate level (PLP) in patients with controlled epilepsy was 76.78±37.24 (nmol/l) (15.5-232.4). In patients with intractable epilepsy, mean plasma 5´- pyridoxal phosphate was 98.67± 80.58 (25.5- 393) nmol/l. There was no statistically significant difference between plasma pyridoxal phosphate levels of these two groups (P═0.430). CONCLUSION Pyridoxine dependent epilepsy is under diagnosed because it is manifested by various types of seizures. Plasma pyridoxal phosphate levels did not differ in our patients with intractable or controlled epilepsy. If PDE is suspected on clinical basis, molecular investigation of ALDH7A1 mutations, as feasible test, until PDE biomarkers becomes available is recommended. |
| Starting Page | 31 |
| Ending Page | 36 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journals.sbmu.ac.ir/ijcn/article/download/9925/12433 |
| PubMed reference number | 28698725v1 |
| Volume Number | 11 |
| Journal | Iranian journal of child neurology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biological Markers Carbamoyl-Phosphate Synthase I Deficiency Disease Drug Resistant Epilepsy Liquid Chromatography Mutation Myoclonic Epilepsy, Juvenile Nanomole/liter Neuroimaging Neurology speciality Patients Pyridoxal Phosphate Seizures Spinal Muscular Atrophy emotional dependency inorganic phosphate pediatric neurology pyridoxine |
| Content Type | Text |
| Resource Type | Article |
