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Erythrocyte phosphate release in essential hypertension.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Walter, Ulrich |
| Copyright Year | 1985 |
| Abstract | In this study erythrocyte phosphate release depended on the intracellular hydrolysis of organic phosphate esters. Total phosphate release was increased in essential hypertension, which suggests an elevated phosphate ester metabolism. Ouabain-sensitive phosphate release was decreased, and the ratio of intracellular Na+/K+ concentrations was increased, a finding consistent with a diminished Na-K-ATPase activity. Furosemide in a concentration of 1.0 mmol/L inhibited erythrocyte phosphate release by half, probably owing to nonspecific membrane effects. The combination of ouabain and furosemide reduced phosphate transfer to a higher degree than did each substance individually. Because of the nonspecific alteration of erythrocyte membrane permeability by furosemide in a concentration of 1.0 mmol/L, ouabain-insensitive, furosemide-sensitive phosphate release and ouabain-insensitive, furosemide-sensitive Na+ efflux (Na-K cotransport) must not be regarded uncritically as specific transport systems. |
| Starting Page | 69 |
| Ending Page | 75 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/7/3_Pt_1/430.full.pdf?download=true |
| Alternate Webpage(s) | http://hyper.ahajournals.org/content/hypertensionaha/7/3_Pt_1/430.full.pdf |
| PubMed reference number | 3997226v1 |
| Volume Number | 7 |
| Issue Number | 3 |
| Part | 1 |
| Journal | Hypertension |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Carbamoyl-Phosphate Synthase I Deficiency Disease Cell Membrane Permeability Erythrocyte Membrane Erythrocytes Furosemide Hypertensive disease Ouabain Phosphoric Acid Esters Potassium Pulmonary Hypertension Sodium inorganic phosphate phosphate ester |
| Content Type | Text |
| Resource Type | Article |
