Loading...
Please wait, while we are loading the content...
Similar Documents
Association of metformin intake with bladder cancer risk and oncologic outcomes in type 2 diabetes mellitus patients
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hu, Jiao Chen, Jin-bo Cui, Yu Zhu, Ye-wen Ren, Wen-biao Zhou, Xiaoyu Liu, Long-fei Chen, He-qun |
| Copyright Year | 2018 |
| Abstract | BACKGROUND Recent clinical trials indicated that metformin intake might play a protective role in the incidence and oncologic outcomes of various cancers. However, its protective effect on bladder cancer remains uncertain. METHODS We performed a meta-analysis to investigate the association between metformin intake and bladder cancer risk as well as oncologic outcomes in diabetes mellitus (DM) patients. A comprehensive literature search was performed using PubMed, Embase, and the Cochrane Central Search Library in December 2017. Hazard ratio (HR) with 95% confidence interval (CI) was pooled. RESULTS A total of 9 retrospective cohort studies with 1,270,179 patients were included. A meta-analysis revealed that metformin intake was associated with an increased recurrence-free survival (HR = 0.55, 95% confidence interval [CI] = 0.35-0.88; P = .01; I = 64%), improved progression-free survival (HR = 0.70, 95% CI = 0.51-0.96; P = .03; I = 33%), and prolonged cancer-specific survival (HR = 0.57, 95% CI = 0.40-0.81; P = .002; I = 0%). However, results demonstrated that metformin intake was not associated with a decreased incidence of bladder cancer (HR = 0.82, 95% CI = 0.61-1.09; P = .17; I = 85%) or an increased overall survival in bladder cancer patients (HR = 0.83, 95% CI = 0.47-1.44; P = .50; I = 64%). CONCLUSION The present meta-analysis indicated that metformin intake could improve the prognosis of bladder cancer patients. Further prospective cohort studies and mechanistic studies are still required to determine the precise role of metformin in the initiation and progression of bladder cancer. |
| File Format | PDF HTM / HTML |
| PubMed reference number | 30045293v1 |
| Alternate Webpage(s) | https://doi.org/10.1097/MD.0000000000011596 |
| DOI | 10.1097/MD.0000000000011596 |
| Journal | Medicine |
| Volume Number | 97 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adiantum sp. Wen 8296 Adult Fanconi syndrome Binge eating disorder Bladder Neoplasm Coffin-Siris syndrome Confidence Intervals Curation Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Extraction Forecast of outcome Ginkgo biloba extract Hazard Ratio Long-Term Synaptic Depression Malignant Neoplasms Manuscripts Metformin Overall Survival Paper Patients Pooled Sample Progression-Free Survival REN gene Taussig-Bing Anomaly Transcription Initiation Urinary Bladder oncology field |
| Content Type | Text |
| Resource Type | Article |
