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Oncologic Outcomes and Predictive Factors for Recurrence Following Robot-Assisted Radical Cystectomy for Urothelial Carcinoma: Multicenter Study from Korea
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shim, Ji Sung Kwon, Tae Gyun Rha, Koon Ho Lee, Young Goo Lee, Ji Youl Jeong, Byong Chang Kim, Jae Yoon Pyun, Jong Hyun Kang, Sung Gu Kang, Seok Ho |
| Copyright Year | 2017 |
| Abstract | The aim of our study was to evaluate intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns in a multicenter series of patients treated with robot-assisted radical cystectomy (RARC) for urothelial carcinoma (UC) of the bladder. Between 2007 and 2015, 346 patients underwent RARC at multiple tertiary referral centers in Korea. Descriptive statistics were used for demographics and perioperative variables. Survival and recurrence were estimated with Kaplan-Meier analysis. Logistic regression models were used to determine predictors of recurrence. Median follow-up was 33 months (interquartile range [IQR], 7-50). The numbers of patients with organ-confined and lymph node (LN)-positive disease were 237 (68.4%) and 68 (19.7%), respectively. LN density (1-20 vs. > 20) was 13.6% and 6.1%, with a median of 17 nodes removed (IQR, 9-23). In logistic regression analysis, type of LN dissection, and pathologic tumor stage were significant predictors of cancer recurrence and death from cancer. Local, distal recurrence and secondary UC occurred in 7 (2.0%), 53 (15.3%), and 4 (1.2%) patients, respectively. The 5-year overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS) were 78%, 84%, and 73%, respectively. At last follow-up, RFS for extended pelvic LN dissection vs. standard pelvic LN dissection was 70% and 47% (P = 0.038). In addition, at last follow-up, LN density (0 vs. 1-20 vs. over 20) was 67%, 41%, and 29%, respectively (P < 0.001). Patients undergoing RARC in this multi-institutional cohort demonstrated intermediate-term oncologic outcomes, predictive factors for recurrence, and recurrence patterns that were not unusual. |
| Starting Page | 1662 |
| Ending Page | 1668 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://synapse.koreamed.org/Synapse/Data/PDFData/0063JKMS/jkms-32-1662.pdf |
| PubMed reference number | 28875611v1 |
| Alternate Webpage(s) | https://doi.org/10.3346/jkms.2017.32.10.1662 |
| DOI | 10.3346/jkms.2017.32.10.1662 |
| Journal | Journal of Korean medical science |
| Volume Number | 32 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adult Fanconi syndrome Anaplastic thyroid carcinoma Anatomic Node Bladder Tissue Cessation of life Coffin-Siris syndrome Complete cystectomy Demography Description Follow-Up Report Lymph Node Tissue Mastectomy, Radical Numerous Overall Survival Patients Pelvic Neoplasms RARG wt Allele Radiotherapy, Computer-Assisted Recurrent Malignant Neoplasm Tertiary Care Centers Tumor stage Urinary Bladder Urothelial Carcinoma lymph nodes oncology field |
| Content Type | Text |
| Resource Type | Article |
