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Kidney-sparing Management Versus Nephroureterectomy for Upper Tract Urothelial Carcinoma: a Systematic Review and Meta-analysis.
| Content Provider | Semantic Scholar |
|---|---|
| Author | She, Dong-Li Xiong, H. U. Fu, Sheng-Jun Yang, Li |
| Copyright Year | 2015 |
| Abstract | PURPOSE To evaluate and update evidence for prognostic effects of kidney-sparing (KS) management and nephroureterectomy (NU) for upper tract urothelial carcinomas. MATERIALS AND METHODS Pubmed, Embase and the Cochrane Library were retrieved for the identification of comparative studies of kidney-sparing procedure and nephroureterectomy for upper tract urothelial carcinoma prior to December 2014. The data were extracted independently by 2 reviewers and the quality of the included studies was assessed. Review Manager 5.3 and STATA 13 were used to perform the meta-analysis. RESULTS Twenty-three observational studies including 1,587 KS and 3,996 NU were evaluated. The results of the meta-analysis showed that nephroureterectomy had no significant benefit with regard to intravesical recurrence (IRFS), metastasis (MFS), cancer specific survival (CSS) and overall survival (OS) except the total tumor recurrence (RFS) when compared with kidney sparing management. The respectively pooled outcomes were HR 1.36 (0.69-2.68, P=0.38) for IRFS, 1.09 (0.59-2.01, P=0.78) for MFS, 1.17 (0.77-1.79, P=0.47) for CSS, 1.50 (0.90-2.48, P=0.12) for OS and 1.61 (1.03-2.51, P=0.04) for RFS. CONCLUSIONS On the whole, kidney-sparing management had equivalent prognostic effect on upper tract urothelial carcinoma as the standard nephroureterectomy except in tumor recurrence. However, the results should be interpreted with caution for lack of stage and grade stratification and multi-center randomized controlled trials are still needed to verify our results. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://journal.waocp.org/article_31346_2da55951b10f1fb4ccf6b3ce2883f711.pdf |
| PubMed reference number | 26320471v1 |
| Volume Number | 16 |
| Issue Number | 14 |
| Journal | Asian Pacific journal of cancer prevention : APJCP |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adult Fanconi syndrome Anaplastic thyroid carcinoma Coffin-Siris syndrome Extraction Kidney Diseases Liver carcinoma Marfan Syndrome Neoplasms Nephroblastoma Numerous Overall Survival Pooled Sample Renal Tissue Stratification Urothelial Carcinoma nephroureterectomy |
| Content Type | Text |
| Resource Type | Article |
