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Should asymptomatic young men with iron deficiency anemia necessarily undergo endoscopy?
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kim, Nam Hee Park, Jung Ho Park, Dong Il Sohn, Chong Il Choi, Kyuyong Jung, Yoon Suk |
| Copyright Year | 2018 |
| Abstract | BACKGROUND/AIMS There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young men (< 50 years) with IDA and those without IDA. METHODS We conducted a case-control study on asymptomatic young men aged < 50 years who underwent both esophagogastroduodenoscopy (EGD) and colonoscopy as part of a health checkup between 2010 and 2014. RESULTS Of 77,864 participants, 128 (0.16%) had IDA and 512 subjects without IDA were matched for several variables including age. Young men with IDA had a significantly higher proportion of colorectal cancer (CRC) (0.8% vs. 0.0%, p = 0.045), villous adenoma (0.8% vs. 0.0%, p = 0.045), and inflammatory bowel disease (IBD; 2.3% vs. 0.4%, p = 0.025) than those without IDA. Additionally, the prevalence of advanced colorectal neoplasia (ACRN) tended to be higher in subjects with IDA than in those without IDA (3.1% vs. 1.0%, p = 0.084). The prevalence of significant lower GI lesions including ACRN and IBD was higher in subjects with IDA than in those without IDA (5.5% vs. 1.4%, p = 0.011). Regarding upper GI lesions, a positive association with IDA was observed only for gastric ulcer (4.7% vs. 1.0%, p = 0.011). CONCLUSION GI lesions including CRC, villous adenoma, IBD, and gastric ulcer were more common in asymptomatic young men with IDA. Our results suggest that EGD and particularly colonoscopy should be recommended even in asymptomatic young men with IDA. |
| Starting Page | 1084 |
| Ending Page | 1092 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://kjim.org/upload/kjim-2016-421.pdf |
| PubMed reference number | 29294595v1 |
| Alternate Webpage(s) | https://doi.org/10.3904/kjim.2016.421 |
| DOI | 10.3904/kjim.2016.421 |
| Journal | The Korean journal of internal medicine |
| Volume Number | 33 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adenoma Adenoma, Villous Cervical Intraepithelial Neoplasia Colorectal Carcinoma Colorectal Neoplasms Esophagogastroduodenoscopy Gastric ulcer Gastrointestinal Diseases Inflammatory Bowel Diseases Intestinal Diseases Intestines Iron deficiency anemia Irritable Bowel Syndrome checkup examination |
| Content Type | Text |
| Resource Type | Article |
