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A Combination of Fecal Immunochemical Test Results and Iron Deficiency Anemia for Detection of Advanced Colorectal Neoplasia in Asymptomatic Men.
| Content Provider | Europe PMC |
|---|---|
| Author | Kim, Nam Hee Lee, Mi Yeon Park, Jung Ho Park, Dong Il Sohn, Chong Il Choi, Kyuyong Jung, Yoon Suk |
| Copyright Year | 2017 |
| Abstract | PurposeA substantial proportion of patients with colorectal cancer (CRC) present with iron deficiency anemia (IDA), and fecal immunochemical test (FIT) has proven to be an effective method for detecting the majority of CRC cases. A combination strategy of FIT results and IDA may be useful for risk stratification for detecting advanced colorectal neoplasia (ACRN). We compared the prevalence of ACRN among four groups stratified by FIT results and the presence of IDA.Materials and MethodsA cross-sectional study was performed on asymptomatic male participants who underwent both FIT and colonoscopy between 2010 and 2014 as part of a comprehensive health screening program in Korea.ResultsOf 17236 participants, 522 (3.0%) showed positive FIT results and 26 (0.2%) had IDA. The mean age of the study participants was 40.8 years. The participants were classified into four groups: positive FIT result/IDA (G1, n=7), positive FIT result/no IDA (G2, n=515), negative FIT result/IDA (G3, n=19), and negative FIT result/no IDA (G4, n=16695). The prevalences of ACRN in G1, G2, G3, and G4 were 28.6, 13.4, 5.3, and 1.5%, respectively (p<0.001) and those of CRC were 28.6, 1.6, 0.0, and 0.01%, respectively (p<0.001). Subjects with positive FIT results and IDA had an increased risk of ACRN and CRC in both group aged <50 and ≥50 years.ConclusionSubjects with positive FIT results and IDA had an increased risk of ACRN. Our results suggest that a combination strategy of FIT and IDA may be helpful in selecting and prioritizing asymptomatic men for colonoscopy. |
| ISSN | 05135796 |
| Volume Number | 58 |
| PubMed Central reference number | PMC5552644 |
| Issue Number | 5 |
| PubMed reference number | 28792133 |
| Journal | Yonsei Medical Journal [Yonsei Med. J] |
| e-ISSN | 19762437 |
| DOI | 10.3349/ymj.2017.58.5.910 |
| Language | English |
| Publisher | Yonsei University College of Medicine |
| Publisher Date | 2017-09-01 |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2017 |
| Subject Keyword | Fecal immunochemical test iron deficiency anemia advanced colorectal neoplasia |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine |
