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Evolution of coinfection with human immunodeficiency virus and hepatitis C virus in patients treated with highly active antiretroviral therapy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Torre, Donato Tambini, Roberto Cadario, F. Barbarini, Giorgio Moroni, Mauro Basilico, Cristina |
| Copyright Year | 2001 |
| Abstract | A retrospective analysis of data from a cohort of patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) who were treated with highly active antiretroviral therapy (HAART) at 3 infectious diseases units in northern Italy was performed. While the patients were receiving HAART, CD4(+) cell counts significantly increased and HIV RNA serum levels decreased. However, no significant overall changes in alanine aminotransferase (ALT) levels and HCV RNA serum levels were observed. Fifteen (4.6%) of 323 patients died within 3 years of follow-up; death was related to cirrhosis in 5 patients (1.6%). No significant difference was observed between cirrhosis-related mortality and mortality related to other causes. Patients with ALT levels >4 times the normal values at initiation of HAART showed a significant decrease in ALT levels, whereas patients with normal ALT levels at initiation of HAART showed a significant increase over time, suggesting that HAART may have long-term beneficial or detrimental effects, depending on patient characteristics. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/cid/33/9/10.1086/322611/3/33-9-1579.pdf?Expires=1492485135&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=g8R3tZn0uNUYSzl4OUIFm358zX1XCPhWJx2BAE4N-Fc6kqMwPTwBubLUjSxsBk393uzdxWoYy8oj38~PT8E64lf8DIqSZMeZOyJbRhqb8NGwy5GvPSz3cVE6MmdT-oi9kJhisS3swYS8fRSNiU9YGxIeENaHf66OJmqHdBLZROiXpXOuzGYly2MVyqmbZL8YE~EZy9v9-sAy2Nk1fw9kfPeT9dpVmIAXeq-uB3nCR0L8XfGylQRCvbW8NKMXbJvXVVGpVrEcN3khnqzgidd~Ue8qE9~xMb~OnUvYky4Ryv31gEwbeorU4m~yJZL3nvQK5NKrU0BJ2J2UaLAQdnTVdA__ |
| PubMed reference number | 11588701v1 |
| Volume Number | 33 |
| Issue Number | 9 |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alanine Transaminase Antiretroviral Therapy, Highly Active Antiretroviral therapy Biological Evolution Cell Count Cessation of life Coinfection Communicable Diseases Fibrosis HCV viral load HIV Infections Hepatitis A Hepatitis C virus Immunologic Deficiency Syndromes Patients RNA Transaminases Transcription Initiation |
| Content Type | Text |
| Resource Type | Article |
