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Hepatotoxicity and Associated Risk Factors in HIV-Infected Patients Receiving Antiretroviral Therapy at Felege Hiwot Referral Hospital, Bahirdar, Ethiopia
| Content Provider | Semantic Scholar |
|---|---|
| Author | Mulu, Wondemagegn Gidey, Bokretsion Chernet, Ambahun Alem, Genetu Abera, Bayeh |
| Copyright Year | 2013 |
| Abstract | BACKGROUND In Human Immunodeficiency Virus (HIV) infected patients on antiretroviral treatment (ART), hepatotoxicity is life threatening. Its outcome may lead to liver failure and death. This study was conducted to determine the rate and determinants of elevated alanine amino transferase (ALT) (referred as >40IU/L for both males and females). METHODS A cross sectional study was conducted on HIV infected individuals who are on ART and suspected of drug resistance at Felege Hiwot Referral Hospital, Bahir Dar from July to December 2012. Venous bloods were collected from each patient and processed parallely to determine ALT, number of HIV RNAs, CD4 and CD8 T cells count, anti hepatitis C virus (HCV) and hepatitis B surface antigen. RESULTS Out of 269 HIV infected patients receiving ART, 32% were confirmed of grades 1-4 levels of elevated ALT. The rate of severe hepatotoxicity (grade 3 and 4) was 1.84%. Patients with increased CD8 T cell counts (P=0.011; AOR=1.82; CI: 1.12 -2.54), alcohol over use (P=0.014; AOR = 1.23; CI: 1.36-3.29) and detectable HIV-1 RNA copies (P=0.015; AOR=2.07; CI: 1.15-3.74) independently predicts the elevation of ALT. CONCLUSIONS In HIV infected patients on ART, extreme elevations of ALT were infrequent but minor elevations were common so that patient-linked variables such as use of alcohol intake must be taken in to account for better clinical management of ART patients. The role of active HCV co-infection on the treatment outcome of ART should be further studied. |
| Starting Page | 217 |
| Ending Page | 226 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.ajol.info/index.php/ejhs/article/download/96725/86045 |
| Alternate Webpage(s) | http://ftp.ncbi.nlm.nih.gov/pub/pmc/9f/ba/EJHS2303-0217.PMC3847531.pdf |
| PubMed reference number | 24307821 |
| Volume Number | 23 |
| Journal | Ethiopian journal of health sciences |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alanine Transaminase Alcohol consumption Aldehyde ferredoxin oxidoreductase activity Cell Count Cellular Phone Cessation of life Chemical and Drug Induced Liver Injury Coinfection Copy (object) D-Alanine Transaminase Ethanol Grade HIV Infections Hepatitis B Surface Antigens Hepatitis C virus Immunologic Deficiency Syndromes Liver Failure Patients Transferase |
| Content Type | Text |
| Resource Type | Article |
