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Inhibitory effect of LY 255283 on the synthesis of leukotriene B4 and thromboxane A2 in human peripheral blood polymorphonuclear leukocytes and monocytes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Uğur, Mehmet Melli, Mehmet |
| Copyright Year | 1993 |
| Abstract | LY 255283 [(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-)1H-tetrazol-5-yl)-heptyloxy) phenyl)ethanone], a specific leukotriene B(4) (LTB(4)) receptor antagonist, inhibited the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187. In human monocytes activated by ionophore it inhibited also the production of thromboxane B(2) (TXB(2)). The effect of LY 255283 on 5-lipoxygenase (5-LO) and LTA(4) hydrolase activities which catalyse the production of LTB(4) and LTA(4) has not been studied yet. It is thought that LY 255283 may inhibit the production of LTB(4) and TXA(2) by antagonising the effect of ionophore-induced LTB(4) on 5-lipoxygenase and cyclooxygenase in human peripheral blood PMNL and monocytes. |
| Starting Page | 407 |
| Ending Page | 409 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 18475555 |
| Volume Number | 2 |
| Journal | Mediators of inflammation |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antigens, Ly Arachidonate 5-Lipoxygenase Calcium Catalysis Hydrolase Ionophores LY 255283 Leukotriene B4 Leukotrienes Peripheral Neuropathy Thromboxane A2 Thromboxane-A Synthase Thromboxanes neutrophil |
| Content Type | Text |
| Resource Type | Article |
