NDLI: Inhibition of alveolar macrophage 5-lipoxygenase metabolism by auranofin.

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Inhibition of alveolar macrophage 5-lipoxygenase metabolism by auranofin.

Content Provider	Semantic Scholar
Author	Peters-Golden, Marc Shelly, Candace A.
Copyright Year	1989
Abstract	We have examined the effect of the oral gold compound auranofin (AF) on calcium ionophore A23187-induced arachidonic acid metabolism in the rat alveolar macrophage. Both reverse-phase high performance liquid chromatographic and radioimmunoassay analyses revealed that AF dose-dependently inhibited leukotriene B4 and 5-hydroxyeicosatetraenoic acid synthesis in a parallel fashion with an IC50 approximately 4.3 micrograms/ml. At the same time, AF augmented A23187-induced arachidonate release and cyclooxygenase metabolism. A possible mechanism for the inhibition of 5-lipoxygenase was suggested by the capacity of AF to dose-dependently deplete ATP (IC50 approximately 5.9 micrograms/ml), a cofactor for 5-lipoxygenase. These data indicate that, at therapeutic concentrations, AF acts in vitro as a selective inhibitor of macrophage 5-lipoxygenase metabolism. This likely represents an important mechanism of action of AF in chronic inflammatory disorders.
Starting Page	137
Ending Page	139
Page Count	3
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://deepblue.lib.umich.edu/bitstream/handle/2027.42/27937/0000363.pdf;jsessionid=1E551E7BE0479C108DE8CCFFBC18F570?sequence=1
PubMed reference number	2499339v1
Volume Number	38
Issue Number	10
Journal	Biochemical pharmacology
Language	English
Access Restriction	Open
Subject Keyword	Adenosine Triphosphate Arachidonate 15-Lipoxygenase Arachidonate 5-Lipoxygenase Arachidonic Acid Auranofin Calcium Gold Compounds Inhibitory Concentration 50 Ionophores Leukotriene B4 Leukotrienes Macrophages, Alveolar
Content Type	Text
Resource Type	Article

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