NDLI: Inhibitory effect of LY 255283 on the synthesis of leukotriene and thromboxane in human peripheral blood polymorphonuclear leukocytes and monocytes

Content Provider	Semantic Scholar
Author	Mellic A.
Copyright Year	2014
Abstract	LY 255283 [(1-(5-ethyl-2-hydroxy-4-(6-methyl-6-)lHtetrazol-5-yl)-heptyloxy) phenyl)ethanone], a specific leukotriene B (LTB4) receptor antagonist, inhibited the production of LTB4 in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A23187. In human monocytes activated by ionophore it inhibited also the production of thromboxane B (TXB2). The effect of LY 255283 on 5-1ipoxygenase (5-LO) and LTA hydrolase activities which catalyse the production of LTB4 and LTA has not been studied yet. It is thought that LY 255283 may inhibit the production of LTB and TXA2 by antagonising the effect of ionophore-induced LTB on 5-1ipoxygenase and cyclooxygenase in human peripheral blood PMNL and monocytes.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://downloads.hindawi.com/journals/mi/1993/675014.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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