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Monitoring immune responses in cancer patients receiving tumor vaccines.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Walker, Edwin B. Disis, Mary L. Nora |
| Copyright Year | 2003 |
| Abstract | Clinical evaluation of therapeutic tumor vaccines has resulted in examination and comparison of the types of immune function assays required to monitor tumor antigen-stimulated T cell effector function in immunized patients. Three of the most commonly used assays include ELISPOT, tetramer assay, and cytokine flow cytometry (CFC). Discussed are the method and principles for each assay and an assessment of important methodological, reagent, and data acquisition issues that are relevant for the accurate and effective use of the assays. The sensitivity and utility of the assays and present arguments advocating their integrated use in future immunomonitoring studies are also discussed. |
| Starting Page | 283 |
| Ending Page | 319 |
| Page Count | 37 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://depts.washington.edu/tumorvac/MultiMedia/Publications/ReviewArticles/2003_InterRevImmun_283-319.pdf |
| Alternate Webpage(s) | https://depts.washington.edu/tumorvac/MultiMedia/Publications/ReviewArticles/2003_InterRevImmun_283-319.pdf |
| PubMed reference number | 12745643v1 |
| Volume Number | 22 |
| Issue Number | 3-4 |
| Journal | International reviews of immunology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Cancer Vaccines Enzyme-Linked Immunospot Assay Flow Cytometry Laboratory Leukemia, B-Cell Lymphocyte Count measurement Neoplasms Paget's Disease, Mammary Patients Reagents Tumor Antigens Tumor Immunology Vaccination childhood lymphocyte depletion Hodgkin's lymphoma cytokine format |
| Content Type | Text |
| Resource Type | Article |
