Loading...
Please wait, while we are loading the content...
Similar Documents
Spontaneous immunity against Bcl-xL in cancer patients.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Andersen, Mads Hald Reker, Sine Kvistborg, Pia Becker, Jürgen C. Straten, P. |
| Copyright Year | 2005 |
| Abstract | It is well-established that peptide epitopes derived from human tumor-associated Ags can be recognized by CTL in the context of the MHC molecule. However, the vast majority of Ags described are not vital for survival and growth of the tumor cells, and immunoselection of Ag-loss variants during immunotherapy has been demonstrated in several cases. Malfunctions in death pathways observed in human cancers are often due to overexpression of antiapoptotic proteins in the Bcl-2 protein family, i.e., Bcl-2, Mcl-1, and Bcl-xL. These antiapoptotic proteins are implicated in cancer development, tumor progression, and drug resistance. The general overexpression of the antiapoptotic members of the Bcl-2 family in cancer and the fact that down-regulation or loss of expression of these proteins as a means of immune escape would impair sustained tumor growth makes them very attractive targets for anticancer immunotherapy. Recently, we identified spontaneous T cell responses against Bcl-2- and Mcl-1-derived peptides in patients suffering from cancers of different origin. In this study, we demonstrate that Bcl-xL is a target for T cell recognition in cancer patients. Thus, we describe spontaneous HLA-A2-restricted cytotoxic T cell responses against peptide epitopes derived from Bcl-xL by means of ELISPOT and flow cytometry stainings, whereas no responses were detected against any of the Bcl-xL epitopes in any healthy controls. Moreover, Bcl-xL-specific T cells are cytotoxic against HLA-matched cancer cells of different origin. Thus, cellular immune responses against apoptosis inhibitors like the Bcl-2 family proteins appear to represent a general feature in cancer. |
| Starting Page | 1 |
| Ending Page | 4 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jimmunol.org/content/jimmunol/175/4/2709.full.pdf |
| Alternate Webpage(s) | http://cancer.cytoluminator.com/cancer-photodynamic-therapy/Bcl-xl%20inhibition%20restores%20apoptotis.pdf |
| PubMed reference number | 16081848v1 |
| Volume Number | 175 |
| Issue Number | 4 |
| Journal | Journal of immunology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Antiapoptotic Agent Apoptosis BCL-XL Protein BCL2 gene BCL2L1 gene Bad protein Cessation of life Chronic Lymphocytic Leukemia Down-Regulation Enzyme-Linked Immunospot Assay Epitopes Flow Cytometry HLA Antigens Histocompatibility Antigens Class II Immune response Immunotherapy Leukemia, B-Cell MCL1 gene Neoplasms Patients Protein Family Staining method Tumor Progression cancer cell |
| Content Type | Text |
| Resource Type | Article |
