NDLI: Slowing progression along the renal disease continuum.

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Slowing progression along the renal disease continuum.

Content Provider	Semantic Scholar
Author	Kopyt, Nelson P.
Copyright Year	2005
Abstract	Patients in whom nephropathy develops as a result of hypertension or diabetes mellitus are more likely to die of cardiovascular disease (CVD) than of kidney disease. An early sign of impending nephropathy is microalbuminuria, defined as urinary excretion of albumin at a rate of 28.8 mg/24 h to 288 mg/24 h. Microalbuminuria is a marker of endothelial dysfunction, vascular injury, and renal disease and CVD, and it is associated with increased risk for myocardial infarction. Oxidative stress and endothelial dysfunction are unifying factors mediated by the renin-angiotensin system in renal disease and CVD. Clinical trials show reduced cardiovascular risk and a reversal of microalbuminuria with the use of agents that affect the renin-angiotensin system: angiotensin-receptor blockers in patients with type 2 diabetes mellitus and nephropathy, or angiotensin-converting enzyme inhibitors in patients with type 1 diabetes mellitus.
Starting Page	26
Ending Page	32
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://jaoa.org/pdfaccess.ashx?url=/data/journals/jaoa/932039/207.pdf
Alternate Webpage(s)	http://pinktwinkies.pbworks.com/f/2.pdf
PubMed reference number	15928338v1
Volume Number	105
Issue Number	4
Journal	The Journal of the American Osteopathic Association
Language	English
Access Restriction	Open
Subject Keyword	ACE protein, human Angiotensin-Converting Enzyme Inhibitors Angiotensins Cardiovascular Diseases Diabetes Mellitus Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus, Non-Insulin-Dependent Hypertensive disease Kidney Diseases Myocardial Infarction Oxidative Stress Patients Renin-angiotensin system Vascular System Injuries
Content Type	Text
Resource Type	Article

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