NDLI: Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome.

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Renin-angiotensin system and angiotensin receptor blockers in the metabolic syndrome.

Content Provider	Semantic Scholar
Author	Prasad, Abhiram Quyyumi, Arshed A.
Copyright Year	2004
Abstract	Activation of the renin-angiotensin system (RAS) occurs in many cardiovascular disorders, and its modulation with angiotensin-converting enzyme (ACE) inhibitors is now established therapy for hypertension, left ventricular dysfunction, diabetic nephropathy, and atherosclerosis. More recently, angiotensin type 1 receptor blockers (ARBs) have shown similar promise.1,2 Research is currently focused on the role of the RAS in the metabolic syndrome (MetS), a disorder characterized primarily by insulin resistance that has emerged as a major risk factor for cardiovascular disease.3 Here, we review how cross talk between angiotensin II (AII) and insulin signaling contributes to the pathophysiology of the MetS and raises the potential for therapeutic use of angiotensin antagonists in its management.
Starting Page	87
Ending Page	106
Page Count	20
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/110/11/1507.full.pdf?download=true
PubMed reference number	15364819v1
Volume Number	110
Issue Number	11
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Angiotensin II Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Angiotensins Arteriopathic disease Atherogenesis Atherosclerosis Cardiovascular Diseases Cerebrovascular accident Coronary Artery Disease Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Diabetic Nephropathy Elfacos OW 100 Heart failure Hyperlipidemia Hypertensive disease Insulin Resistance Kidney Diseases Metabolic Syndrome X Metastatic Neoplasm NLRP3 gene Receptor, Angiotensin, Type 1 Renin-angiotensin system Thrombophilia Ventricular Dysfunction Ventricular Dysfunction, Left glucose metabolism
Content Type	Text
Resource Type	Article

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