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The rationale for early management of chronic renal insufficiency.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Muirhead, Norman |
| Copyright Year | 2001 |
| Abstract | Several strategies are available to delay progression of renal disease and the development of associated co-morbidities. Hypertension is a strong independent risk factor for end-stage renal disease (ESRD) and there is consensus that blood pressure (BP) management is an important aspect of care in patients with chronic renal insufficiency (CRI). Clinical studies have shown that angiotensin-converting enzyme (ACE) inhibitors have renoprotective properties, independent of their antihypertensive effects, which can delay the onset of ESRD. Studies have also shown that intensive therapy of both type 1 and type 2 diabetes patients, to give near normal blood glucose concentrations, can reduce the incidence of progressive clinical proteinuria and may, therefore, protect against ESRD. Additionally, data are emerging that treatment of renal anaemia with epoetin can reduce mortality and delay the onset of dialysis in CRI patients, but these encouraging results need to be confirmed in large prospective studies. In conclusion, control of BP and hyperglycaemia, as well as use of ACE inhibitors and anaemia treatment, all have potential in delaying the progression of CRI or improving patient outcomes. If benefit is proven in future studies, these strategies will be most effective if implemented early in the course of CRI. |
| Starting Page | 297 |
| Ending Page | 312 |
| Page Count | 16 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/ndt/16/suppl_7/10.1093_ndt_16.suppl_7.51/3/160051.pdf?Expires=1496467935&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=O1wQR4uMD5ld0U6dDBR0AtEIpE3upQoOflFjtXlTtYGE531bCtPP0qJi29loJbLXorcAKu4oEWKkSS9IFuvhei447607pKAlzIQC6gvu51oNQ-DBtOF7hvONI3ClqYRLJv21bu5p9cQerpyizIuAVpStcgOMkUANkNROm6xyMgNfzBhP2sDKtTMXqCxVaHcRGFSxhbZrIiq-bnnUYBGMqVN6vUrUQyeP2I8x870WpP621uLl3Dl~45CbeiqOa4lNAL2DTz4zBKJN7mplQ0QpX8qNV5SWa8PxxxC5oxHPdLLwYqMl~dW~MwZZr~2tnq-TI8A7x6kO1A6SPMaEIq-ERg__ |
| PubMed reference number | 11590258v1 |
| Volume Number | 16 |
| Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Angiotensin Receptor Antagonists Angiotensin-Converting Enzyme Inhibitors Angiotensins Antihypertensive Agents Chronic Kidney Insufficiency Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Diabetic Nephropathy Dietary Proteins EPO protein, human Epidemiology Glucose Hematological Disease Hyperglycemia Hypertensive disease Kidney Diseases Kidney Failure, Chronic Morbidity - disease rate Patients Peptidyl-Dipeptidase A Renal Insufficiency renal anemia |
| Content Type | Text |
| Resource Type | Article |
