NDLI: A competitive antagonist of nmda receptors cgp 40116 attenuates experimental symptoms of schizophrenia evoked by mk-801.

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A competitive antagonist of nmda receptors cgp 40116 attenuates experimental symptoms of schizophrenia evoked by mk-801.

Content Provider	CiteSeerX
Author	Pharmacol, Pol J. Czyrak, Anna Wêdzony, Krzysztof
Abstract	In the present study, the interaction between a noncompetitive [(+)-MK-801] and a competitive (CGP 40116) NMDA receptor antagonists was tested in two different behavioral paradigms: locomotor activity test and prepulse inhibition of the acoustic startle reflex. Additionally, their effects on working memory and selective attention were evaluated in the delayed alternation task. All above paradigms served to model the symptoms of schizophrenia. It was found that locomotor stimulatory effect of (+)-MK-801 (0.4 mg/kg) was antagonized by prior administration of CGP 40116 (5 mg/kg). Lower doses of CGP 40116 (1.25 and 2.5 mg/kg) were ineffective. CGP 40116 given alone did not influence locomotor activity in rats. It was also shown that CGP 40116 antagonized the disruption of the process of sensorimotor gating evoked by (+)-MK-801. On the contrary, both CGP 40116 and (+)-MK-801 increased a number of errors in the delayed alternation test revealing detrimental effect of CGP 40116 on spatial working memory and selective attention even at a lower dose than that required to antagonize the effects
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Subject Keyword	Competitive Antagonist Nmda Receptor Cgp Selective Attention Mg Kg Detrimental Effect Locomotor Activity Test Acoustic Startle Reflex Prepulse Inhibition Prior Administration Different Behavioral Paradigm Nmda Receptor Antagonist Present Study Locomotor Stimulatory Effect Locomotor Activity Delayed Alternation Task Delayed Alternation Test
Content Type	Text

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