Loading...
Please wait, while we are loading the content...
Similar Documents
Ineffectiveness of trimethoprim-sulfamethoxazole prophylaxis and the importance of bacterial and viral coinfections in African children with Pneumocystis carinii pneumonia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Madhi, Shabir A. Cutland, Clare Louise Ismail, Kuraisha O'Reilly, Cathryn Mancha, Archana |
| Copyright Year | 2002 |
| Abstract | African human immunodeficiency virus type 1 (HIV-1)-infected children were evaluated to define the burden of Pneumocystis carinii pneumonia (PCP) and its interaction with bacterial and viral pathogens. P. carinii was identified in 101 (43.7%) of 231 episodes of pneumonia among 185 HIV-1-infected children (median age, 4.5 months; range, 1.7-27.3 months). Receipt of trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis was not associated with a significant reduction (36%; 95% confidence interval [CI], -15.4% to 64.5%) in isolation of P. carinii among children considered to have received adequate prophylaxis (37.7% of children) compared with children who had never received any prophylaxis (48.5% of children). However, deaths among children with PCP who had been taking TMP-SMX prophylaxis were markedly reduced (98.6%; 95% CI, 89.1%-99.8%) compared with children who were not taking prophylaxis. Concurrent P. carinii infection was observed in 6 of 18, 11 of 26, and 4 of 6 HIV-1-infected children who had bacteremia, a respiratory virus isolated, or Mycobacterium species isolated, respectively. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/cid/35/9/10.1086/343049/2/35-9-1120.pdf?Expires=1492572856&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=J9FBcKdlgsHZACOb8shmXm9dTFHISKNcVgtMsqn3IBAjgqaFRSF98Zv3H9pevwST6jxNLFQomlfhVisUvOhXdXMuuuYCZyljyoFoWz~mB20NVYsHf2q0LPdAVwbg4bi~ce0XugnAMYdzCb25HJ9rs6fFNf9LYiAmsmxPg25vaccDs0OxP8AQUMTyCaTK6C1Gm-i1JK-7raO1B4jFvgWLEib8butkb4hSXI2t4aTSkGF-MJN52A1piU7AR1SjpU5zMqossON02SoBIMupRLD9PAJ0o~6H65Rt~IelQoiZ1Y0YtqqJeAk~Jjhet9llQVFunYgHxdXMxHVq46mvAl1bCw__ |
| PubMed reference number | 12384847v1 |
| Volume Number | 35 |
| Issue Number | 9 |
| Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 101 Mouse Bacteremia Cessation of life Coinfection Confidence Intervals Genus Mycobacterium Genus Pneumocystis HIV Infections HIV-1 Immunologic Deficiency Syndromes Parainfluenza Virus 2, Human Pneumocystis jiroveci pneumonia Sulfamethoxazole Trimethaphan Trimethoprim Trimethoprim-Sulfamethoxazole Combination |
| Content Type | Text |
| Resource Type | Article |
