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Haloperidol-induced blockade of induction of long-term potentiation in perforant path-dentate gyrus pathway in chronically prepared rabbits
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jibiki, Itsuki Wakita, Shigeki Kubota, Takashi Kurokawa, Kenzo Yamaguchi, Nariyoshi |
| Copyright Year | 1993 |
| Abstract | We investigated the effects of the representative neuroleptic and dopamine receptor antagonist haloperidol (HPD) on the induction of long-term potentiation (LTP) or on the previously induced LTP in the perforant path-dentate gyrus pathway in chronically prepared rabbits. The IP HPD injection of 0.8 mg/kg blocked the induction of LTP when it was given before LTP-inducing tetanic stimulations, although this dose showed virtually no effect on the baseline control responses in the perforant path-dentate gyrus pathway to single shocks. However, neither 0.8-mg/kg nor 1.6-mg/kg HPD doses affected the previously induced LTP. The possible mechanisms underlying these results, notably the HPD-induced blockade of LTP induction, are discussed, especially in association with the inhibitory action of HPD on calmodulin-mediated events rather than dopaminergic function. |
| Starting Page | 847 |
| Ending Page | 852 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0091-3057(93)90211-B |
| PubMed reference number | 8309965 |
| Journal | Medline |
| Volume Number | 46 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/009130579390211B |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/009130579390211B?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0091-3057%2893%2990211-B |
| Journal | Pharmacology Biochemistry and Behavior |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
