NDLI: Long-term potentiation expands information content of hippocampal dentate gyrus synapses.

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Long-term potentiation expands information content of hippocampal dentate gyrus synapses.

Content Provider	Semantic Scholar
Author	Bromer, Cailey Thekla Bartol, Thomas M. Bowden, Jared B. Hubbard, Dusten D. Hanka, Dakota C. González, Paola Vargas Kuwajima, Masaaki Mendenhall, John M. Parker, Patrick H. Abraham, Wickliffe C. Sejnowski, Terrence J. Harris, Kristen M.
Copyright Year	2018
Abstract	An approach combining signal detection theory and precise 3D reconstructions from serial section electron microscopy (3DEM) was used to investigate synaptic plasticity and information storage capacity at medial perforant path synapses in adult hippocampal dentate gyrus in vivo. Induction of long-term potentiation (LTP) markedly increased the frequencies of both small and large spines measured 30 minutes later. This bidirectional expansion resulted in heterosynaptic counterbalancing of total synaptic area per unit length of granule cell dendrite. Control hemispheres exhibited 6.5 distinct spine sizes for 2.7 bits of storage capacity while LTP resulted in 12.9 distinct spine sizes (3.7 bits). In contrast, control hippocampal CA1 synapses exhibited 4.7 bits with much greater synaptic precision than either control or potentiated dentate gyrus synapses. Thus, synaptic plasticity altered total capacity, yet hippocampal subregions differed dramatically in their synaptic information storage capacity, reflecting their diverse functions and activation histories.
Starting Page	E2410
Ending Page	E2418
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://papers.cnl.salk.edu/PDFs/Long-term%20Potentiation%20Expands%20Information%20Content%20of%20Hippocampal%20Dentate%20Gyrus%20Synapses%202018-4512.pdf
Alternate Webpage(s)	http://synapseweb.clm.utexas.edu/sites/default/files/synapseweb/files/2018_bromer_harris_pnas_ltp_expands_information_content.pdf
PubMed reference number	29463730v1
Alternate Webpage(s)	https://doi.org/10.1073/pnas.1716189115
DOI	10.1073/pnas.1716189115
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume Number	115
Issue Number	10
Language	English
Access Restriction	Open
Subject Keyword	CA1 field Dendrites Electron Microscopy Hippocampus (Brain) Long-Term Potentiation Neuronal Plasticity Perforant Pathway Signal Detection (Psychology) Structure of dentate gyrus Synapses Vertebral column chemosensitization/potentiation granule cell
Content Type	Text
Resource Type	Article

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